BAFF/TNFSF13B 蛋白, Canine (HEK293, Fc)

The BAFF/TNFSF13B protein is part of the TNF family and is critical in the regulation of immune responses and cell survival. It is also called B cell activating factor and plays a crucial role in B cell development, activation and survival by binding to receptors such as BAFF-R. BAFF/TNFSF13B Protein, Canine (HEK293, Fc) is the recombinant canine-derived BAFF/TNFSF13B protein, expressed by HEK293 , with N-hFc labeled tag. The total length of BAFF/TNFSF13B Protein, Canine (HEK293, Fc) is 150 a.a., with molecular weight of ~45.5 kDa.

BAFF/TNFSF13B 蛋白属于肿瘤坏死因子 (TNF) 家族，这是一组参与调节免疫反应和细胞存活的细胞因子。BAFF/TNFSF13B，也称为B细胞激活因子，在B细胞的发育、激活和存活中起着至关重要的作用。它与其受体结合，包括 BAFF 受体 (BAFF-R)，并促进 B 细胞增殖、抗体产生和成熟 B 细胞的维持。BAFF/TNFSF13B 在免疫系统的发育和功能中特别重要，因为它有助于调节 B 细胞稳态和免疫耐受。BAFF/TNFSF13B 信号传导失调与多种自身免疫性疾病和 B 细胞恶性肿瘤有关。了解 BAFF/TNFSF13B 在正常生理学和疾病病理学中的作用可以为涉及 B 细胞功能障碍或失调的疾病的潜在治疗方法提供有价值的见解。

Measured by its binding ability in a functional ELISA. When Recombinant BCMA Protein is immobilized at 2 µg/mL (100 µL/well) can bind Recombinant Canine BAFF. The ED₅₀ for this effect is 4.397 ng/mL.

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  Measured by its binding ability in a functional ELISA. When Recombinant BCMA Protein is immobilized at 2 µg/mL (100 µL/well) can bind Recombinant Canine BAFF. The ED₅₀ for this effect is 4.397 ng/mL.

Canine

HEK293

N-hFc

C4NZX1 (A143-L292)

485545  [NCBI]

QGPEETVTQDCLQLIADSDTPTIRKGAYTFVPWLLSFKRGRALEEKENKILVKEAGYFFIYSQVLYTDNTFAMGHLIQRKKVHVFGDELSLVTLFRCIQNMPETLPNNSCYSAGIAKLEEGDELQLAIPREDAKISRDGDGTFFGALKLL

Approximately 45-50 kDa due to the glycosylation.

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  Greater than 95% as determined by reducing SDS-PAGE.

无菌粉末

Lyophilized from a 0.2 μm filtered solution of PBS, pH 7.4, 5% trehalose, 5% mannitol and 0.01% Tween80.

<1 EU/μg, determined by LAL method.

It is not recommended to reconstitute to a concentration less than 100 μg/mL in ddH₂O.

Stored at -20°C for 2 years. After reconstitution, it is stable at 4°C for 1 week or -20°C for longer (with carrier protein). It is recommended to freeze aliquots at -20°C or -80°C for extended storage.

Room temperature in continental US; may vary elsewhere.