BAFFR/TNFRSF13C 蛋白, Cynomolgus (HEK293, His)

BAFF Receptor (B-cell activating factor receptor, BAFF-R), also known as TNFRSF13C and BR3, is a membrane protein of the TNF receptor superfamily which recognizes BAFF. BAFF Receptor is the crucial receptor for B-cell survival and also is a potent costimulator of both B and T cell activation^[1]. BAFFR/TNFRSF13C Protein, Cynomolgus (HEK293, His) is a recombinant protein with a C-Terminal His label, It consists of 70 amino acids (S7-G76) and is produced in HEK293 cells.

BAFF 受体在所有 B 细胞（浆细胞除外）上表达，包括未成熟、移行、成熟、记忆和生发中心 B 细胞以及浆细胞^[2]，而 BAFF-R也在滤泡辅助 T 细胞 (TFH) 上表达^[3]。
人 BAFF 受体蛋白的氨基酸序列与小鼠和大鼠 BAFF 受体蛋白的同源性较低。
BAFF 受体与 BAFF 结合，并将 TNF 受体相关因子 3 (TRAF-3) 和 TRAF-2 招募到 BAFF-R 分子的胞内结构域。TRAF3 与 BAFF-R 的结合逆转了未结合/细胞质 TRAF3 对替代 NF-κB2 信号通路的抑制作用。它释放 NF-κB 诱导激酶 (NIK)，使 κB 激酶 1 (IKK1) 抑制剂磷酸化，从而激活非经典 NF-κB。BAFF-R 信号传导对于外周 B 细胞存活和分化、生发中心形成、浆细胞存活以及 IgG 和 IgE 类别转换至关重要^[2]。
BAFF 受体与 BAFF 结合，介导 B -细胞存活、增殖和分化，并参与小鼠模型中次级卵泡和自身免疫性疾病中三级淋巴结构中 GC 的形成^[3]。BAFF/BAFF-R 信号转导对于原代 B 细胞的存活、分化和稳态至关重要^[4]。表达缺陷 BAFF-R 的 A/WySnJ 小鼠会破坏 B 细胞成熟，与 BAFF 缺陷小鼠中观察到的情况类似^[5]。

Cynomolgus

HEK293

C-His

A0A2K5V1K1 (S7-G76)

/

13-25 kDa

Greater than 95% as determined by Tris-Bis PAGE

<1 EU/μg, determined by LAL method.

• [1]. Rodig SJ, et al. BAFF-R, the major B cell-activating factor receptor, is expressed on most mature B cells and B-cell lymphoproliferative disorders. Hum Pathol. 2005 Oct;36(10):1113-9.  [Content Brief]

  [2]. Thompson N, et al. Exploring BAFF: its expression, receptors and contribution to the immunopathogenesis of Sjögren's syndrome. Rheumatology (Oxford). 2016 Sep;55(9):1548-55.  [Content Brief]

  [3]. Carrillo-Ballesteros FJ, et al. B-cell activating factor receptor expression is associated with germinal center B-cell maintenance. Exp Ther Med. 2019 Mar;17(3):2053-2060.  [Content Brief]

  [4]. Zheng N, et al. BAFF promotes proliferation of human mesangial cells through interaction with BAFF-R. BMC Nephrol. 2015 May 15;16:72.  [Content Brief]

  [5]. Ng LG, et al. B cell-activating factor belonging to the TNF family (BAFF)-R is the principal BAFF receptor facilitating BAFF costimulation of circulating T and B cells. J Immunol. 2004 Jul 15;173(2):807-17.  [Content Brief]

  [6]. Warnatz K, et al. B-cell activating factor receptor deficiency is associated with an adult-onset antibody deficiency syndrome in humans. Proc Natl Acad Sci U S A. 2009 Aug 18;106(33):13945-50.  [Content Brief]