Basigin/CD147 蛋白, Mouse (304a.a, HEK293, His)

The Basigin/CD147 protein is essential for retinal maturation and development, acting as a NXNL1 receptor to promote the survival of retinal cone photoreceptor cells. Basigin/CD147 Protein, Mouse (304a.a, HEK293, His) is the recombinant mouse-derived Basigin/CD147 protein, expressed by HEK293 , with C-6*His labeled tag.

Basigin/CD147 蛋白对于正常视网膜成熟和发育是不可或缺的，作为 NXNL1 的关键细胞表面受体，对 NXNL1 介导的视网膜锥光感受器的存活做出显着贡献。Basigin/CD147 与葡萄糖转运蛋白 SLC16A1/GLUT1 和 NXNL1 合作，通过增强有氧糖酵解和促进葡萄糖进入光感受器来促进视网膜锥体存活。它作为亲环蛋白的信号传导受体，在与免疫细胞趋化和粘附相关的 PPIA/CYPA 和 PPIB/CYPB 依赖性信号传导中发挥重要作用。此外，Basigin/CD147 在将单羧酸转运蛋白 SLC16A1、SLC16A3 和 SLC16A8 靶向质膜方面发挥着关键作用。作为内皮细胞中血管内皮生长因子受体 2 (KDR/VEGFR2) 的辅助受体，它增强 VEGFA 介导的激活和下游信号传导，通过 EPAS1/HIF2A 介导的 VEGFA 和 KDR/VEGFR2 上调促进血管生成。此外，Basigin/CD147 在精子发生中发挥着至关重要的作用，介导生殖细胞和支持细胞之间的相互作用，并被证明对于生殖细胞发育和分化为圆形精子细胞至关重要。

Mouse

HEK293

C-6*His

P18572-1 (A22-R325)

12215  [NCBI]

AAGFLKAPLSQERWAGGSVVLHCEAVGSPIPEIQWWFEGNAPNDSCSQLWDGARLDRVHIHAAYRQHAASSLSVDGLTAEDTGTYECRASSDPDRNHLTRPPRVKWVRAQASVVVLEPGTIQTSVQEVNSKTQLTCSLNSSGVDIVGHRWMRGGKVLQEDTLPDLHTKYIVDADDRSGEYSCIFLPEPVGRSEINVEGPPRIKVGKKSEHSSEGELAKLVCKSDASYPPITDWFWFKTSDTGEEEAITNSTEANGKYVVVSTPEKSQLTISNLDVNVDPGTYVCNATNAQGTTRETISLRVRSR

45-65 kDa

Greater than 90% as determined by reducing SDS-PAGE.

无菌粉末.

Lyophilized from a 0.2 μm filtered solution of PBS, pH 7.4.

<1 EU/μg, determined by LAL method.

It is not recommended to reconstitute to a concentration less than 100 μg/mL in ddH₂O. For long term storage it is recommended to add a carrier protein (0.1% BSA, 5% HSA, 10% FBS or 5% Trehalose).

Stored at -20°C for 2 years. After reconstitution, it is stable at 4°C for 1 week or -20°C for longer (with carrier protein). It is recommended to freeze aliquots at -20°C or -80°C for extended storage.

Room temperature in continental US; may vary elsewhere.