Bcl-2-like 蛋白 11 蛋白, Human (His)

Bcl-2-like protein 11 (BCL2L11), despite its classification, does not interact with humanin. This unique feature distinguishes BCL2L11 from expected protein-protein interactions typically associated with Bcl-2 family members. Bcl-2-like Protein 11 Protein, Human (His) is the recombinant human-derived Bcl-2-like Protein 11 protein, expressed by E. coli , with N-6*His labeled tag.

Bcl-2 样蛋白 11 (BCL2L11)，也称为 BIM，参与调节其细胞功能的关键蛋白质相互作用。磷酸化的 BCL2L11 与 USP27X 相互作用，导致 BCL2L11 去泛素化和随后的稳定。这种相互作用表明 BCL2L11 水平存在调节机制，影响其在细胞凋亡途径中的作用。此外，BCL2L11 与护脑素相互作用，这种相互作用通过防止 BIM 诱导的细胞凋亡发挥保护功能。BCL2L11、USP27X 和护脑素之间错综复杂的相互作用凸显了细胞凋亡调节的复杂性，并强调了翻译后修饰在调节 BCL2L11 稳定性和活性方面的重要性。需要进一步的研究来充分阐明细胞过程中这些相互作用的分子机制和生理学意义以及对治疗干预的潜在影响。

Human

E. coli

N-6*His

O43521-1 (M1-R180)

10018

MAKQPSDVSSECDREGRQLQPAERPPQLRPGAPTSLQTEPQGNPEGNHGGEGDSCPHGSPQGPLAPPASPGPFATRSPLFIFMRRSSLLSRSSSGYFSFDTDRSPAPMSCDKSTQTPSPPCQAFNHYLSAMASMRQAEPADMRPEIWIAQELRRIGDEFNAYYARRVFLNNYQAAEDHPR

approximately 25 kDa

• 
  Greater than 95% as determined by reducing SDS-PAGE.

溶液.

Supplied as a 0.2 μm filtered solution of 50 mM Tris-HCL, 300 mM NaCL, pH 8.0, 10% Glycerol.

<1 EU/μg, determined by LAL method.

N/A.

Stored at -80°C for 1 year. It is stable at -20°C for 3 months after opening. It is recommended to freeze aliquots at -80°C for extended storage. Avoid repeated freeze-thaw cycles.

Shipping with dry ice.