C-Reactive 蛋白, Mouse (HEK293, His)

C-reactive protein (CRP) has cholesterol-binding, complement C1q complex-binding, and low-density lipoprotein particle-binding activities, and plays a role in complement activation, gene expression regulation, and superoxide anion generation. It is located in filopodia and growth cones and is expressed in embryos and liver. C-Reactive Protein, Mouse (HEK293, His) is the recombinant mouse-derived C-Reactive protein, expressed by HEK293 , with C-His labeled tag.

反应蛋白 (CRP) 预计具有多种功能，例如胆固醇结合活性、补体成分 C1q 复合物结合活性和低密度脂蛋白颗粒结合活性，预计将在多种过程中发挥作用，包括通过补体激活经典途径、基因表达的调节和超氧阴离子生成的调节。预计它在血管收缩的上游发挥作用，并预计位于丝状伪足和生长锥中，在细胞外空间中具有活性。这种蛋白质在胚胎和肝脏中表达。CRP 的人类直系同源物与多种疾病有关，包括川崎病、自身免疫性疾病、黄斑变性、大脑中动脉梗塞和肾炎。值得注意的是，CRP 在胚胎和成体阶段在肝脏等组织中表现出偏向表达。

Mouse

HEK293

C-His

P14847/NP_031794.3 (H20-S225)

12944  [NCBI]

HEDMFKKAFVFPKESDTSYVSLEAESKKPLNTFTVCLHFYTALSTVRSFSVFSYATKKNSNDILIFWNKDKQYTFGVGGAEVRFMVSEIPEAPTHICASWESATGIVEFWIDGKPKVRKSLHKGYTVGPDASIILGQEQDSYGGDFDAKQSLVGDIGDVNMWDFVLSPEQISTVYVGGTLSPNVLNWRALNYKAQGDVFIKPQLWS

25-30 kDa

• 
  Greater than 95% as determined by reducing SDS-PAGE.

无菌粉末

Lyophilized from a 0.22 μm filtered solution of PBS, pH 7.4.

<1 EU/μg, determined by LAL method.

It is not recommended to reconstitute to a concentration less than 100 μg/mL in ddH₂O. For long term storage it is recommended to add a carrier protein (0.1% BSA, 5% HSA, 10% FBS or 5% Trehalose).

Stored at -20°C for 2 years. After reconstitution, it is stable at 4°C for 1 week or -20°C for longer (with carrier protein). It is recommended to freeze aliquots at -20°C or -80°C for extended storage.

Room temperature in continental US; may vary elsewhere.