C1QA 蛋白, Mouse (His-SUMO)

The C1QA protein helps form C1, the starting component of the serum complement system. C1q binds to the zymogens C1r and C1s, resulting in C1 assembly. C1QA Protein, Mouse (His-SUMO) is the recombinant mouse-derived C1QA protein, expressed by E. coli , with N-6*His, N-SUMO labeled tag. The total length of C1QA Protein, Mouse (His-SUMO) is 223 a.a., with molecular weight of ~39.6 kDa.

C1QA 蛋白在 C1（血清补体系统的起始成分）的形成中起着关键作用。C1q 与酶原 C1r 和 C1s 结合，导致 C1 的组装。C1q 的胶原蛋白样区域与 Ca(2+) 依赖性 C1r(2)C1s(2) 酶原复合物结合，C1q 的球状头与 IgG 或 IgG 的 Fc 区域相互作用时，C1 就会被有效激活。免疫复合物内的 IgM 抗体。活性C1由C1q、C1r和C1s以1:2:2的摩尔比组成的钙依赖性三分子复合物。C1q 亚组分由 9 个亚基组成，其中 6 个亚基形成 A 链和 B 链的二硫键连接的二聚体，其余 3 个形成 C 链的二硫键连接的二聚体。此外，C1QA 通过其 C 末端与 CD33 相互作用，激活 CD33 抑制基序。

Mouse

E. coli

N-6*His;N-SUMO

P98086 (E23-A245)

12259  [NCBI]

EDVCRAPNGKDGAPGNPGRPGRPGLKGERGEPGAAGIRTGIRGFKGDPGESGPPGKPGNVGLPGPSGPLGDSGPQGLKGVKGNPGNIRDQPRPAFSAIRQNPMTLGNVVIFDKVLTNQESPYQNHTGRFICAVPGFYYFNFQVISKWDLCLFIKSSSGGQPRDSLSFSNTNNKGLFQVLAGGTVLQLRRGDEVWIEKDPAKGRIYQGTEADSIFSGFLIFPSA

Approximately 39.6 kDa

Greater than 90% as determined by reducing SDS-PAGE.

无菌粉末

Lyophilized from a 0.2 μm solution of 10 mM Tris-HCl, 1 mM EDTA, 6% Trehalose, pH 8.0.

<1 EU/μg, determined by LAL method.

It is not recommended to reconstitute to a concentration less than 100 μg/mL in ddH₂O.

Stored at -20°C for 2 years. After reconstitution, it is stable at 4°C for 1 week or -20°C for longer (with carrier protein). It is recommended to freeze aliquots at -20°C or -80°C for extended storage.

Room temperature in continental US; may vary elsewhere.