C1s/Complement component C1s 蛋白, Human (HEK293, His)

C1s/Complement component C1s, a serine protease and B chain, forms C1 with C1q and C1r, initiating the classical complement pathway. Activated by C1r, C1s then activates downstream components C2 and C4, crucially driving the complement system cascade. C1s/Complement component C1s Protein, Human (HEK293, His) is the recombinant human-derived C1s/Complement component C1s protein, expressed by HEK293, with C-His labeled tag. The total length of C1s/Complement component C1s Protein, Human (HEK293, His) is 673 a.a., with molecular weight of 55-60 kDa (light chain), 32-35 kDa (heavy chain).

C1s 是一种丝氨酸蛋白酶，构成 B 链，与 C1q 和 C1r 一起组装形成 C1，C1 是补体系统经典途径中的初始组件。C1r 促进 C1s 的激活，使其能够随后激活下游组件 C2 和 C4，从而启动补体系统功能所必需的级联事件。

Human

HEK293

C-His

P09871 (E16-D688)

716  [NCBI]

55-60 kDa (light chain), 32-35 kDa (heavy chain)

Greater than 95% as determined by Tris-Bis PAGE.

无菌粉末.

Lyophilized from a 0.22 μm filtered solution of PBS, pH 7.4. Normally 8% trehalose is added as protectant before lyophilization.

<1 EU/μg, determined by LAL method.

It is not recommended to reconstitute to a concentration less than 100 μg/mL in ddH₂O.

Stored at -20°C for 2 years. After reconstitution, it is stable at 4°C for 1 week or -20°C for longer (with carrier protein). It is recommended to freeze aliquots at -20°C or -80°C for extended storage.

Room temperature in continental US; may vary elsewhere.