C5AR2 蛋白, Human (Cell-Free, His)

The C5AR2 protein is a receptor for C3a, C4a, and C5a peptides as well as ASP/C3adesArg, C4adesArg, and C5adesArg, and is weakly coupled to G(i)-mediated signaling pathways. It interacts with C3 and exhibits higher affinity for the lipogenic hormone ASP. C5AR2 Protein, Human (Cell-Free, His) is the recombinant human-derived C5AR2 protein, expressed by E. coli Cell-free , with C-10*His labeled tag. The total length of C5AR2 Protein, Human (Cell-Free, His) is 337 a.a., with molecular weight of 38.9 kDa.

C5AR2 蛋白充当趋化性和炎症性 C3a、C4a 和 C5a 过敏毒素肽及其脱氨基形式 ASP/C3adesArg、C4adesArg 和 C5adesArg 的受体。虽然 C5AR2 与 G(i) 介导的信号通路耦合较弱，但它与 C3 相互作用，特别是与脂肪生成激素 ASP 具有更高的亲和力。这种相互作用增强了 GPR77 的磷酸化和激活，导致 ARRB2 募集到细胞表面以及随后的 GRP77 内吞作用。这种复杂的信号传导机制凸显了 C5AR2 参与介导过敏毒素肽和 ASP 的反应，表明其在调节免疫和炎症过程中的作用。

Human

E. coli Cell-free

C-10*His

Q9P296 (M1-V337)

27202

MGNDSVSYEYGDYSDLSDRPVDCLDGACLAIDPLRVAPLPLYAAIFLVGVPGNAMVAWVAGKVARRRVGATWLLHLAVADLLCCLSLPILAVPIARGGHWPYGAVGCRALPSIILLTMYASVLLLAALSADLCFLALGPAWWSTVQRACGVQVACGAAWTLALLLTVPSAIYRRLHQEHFPARLQCVVDYGGSSSTENAVTAIRFLFGFLGPLVAVASCHSALLCWAARRCRPLGTAIVVGFFVCWAPYHLLGLVLTVAAPNSALLARALRAEPLIVGLALAHSCLNPMLFLYFGRAQLRRSLPAACHWALRESQGQDESVDSKKSTSHDLVSEMEV

38.9 kDa

Greater than 90% as determined by reducing SDS-PAGE.

<1 EU/μg, determined by LAL method.