C7/Complement component C7 蛋白, Human (HEK293, Fc)

C7, also known as complement component C7 protein, is a key component of the membrane attack complex (MAC) and plays a key role in innate and adaptive immune responses. As a component of MAC, C7 actively participates in the formation of target cell plasma membrane pores. C7/Complement component C7 Protein, Human (HEK293, Fc) is the recombinant human-derived C7/Complement component C7 protein, expressed by HEK293 , with C-hFc labeled tag. The total length of C7/Complement component C7 Protein, Human (HEK293, Fc) is 843 a.a., with molecular weight of ~118 kDa.

补体成分 C7 是膜攻击复合物 (MAC) 的组成部分，是先天性和适应性免疫反应的关键效应物。MAC 通过在靶细胞质膜上形成孔，导致细胞裂解和破坏而发挥关键作用。C7 在此过程中充当膜锚，它可以作为单体或二聚体存在，当作为 C5b-7 复合物的一部分时，有可能形成多聚玫瑰花结。MAC 组装从 C5 蛋白水解裂解为 C5a 和 C5b 开始，随后，C5b 依次与 C6、C7、C8 和成孔亚基 C9 的多个拷贝结合。这一精心安排的序列凸显了 C7 在 MAC 组装中的重要作用，有助于免疫系统消除靶细胞的能力。

Human

HEK293

C-hFc

P10643 (M1-Q843)

730  [NCBI]

Approximately 118 kDa

Greater than 90% as determined by reducing SDS-PAGE.

溶液

Supplied as a 0.2 μm filtered solution of PBS, 5 % Trehalose, 8% Glycerol, pH 7.4.

<1 EU/μg, determined by LAL method.

N/A.

Stored at -80°C for 1 year. It is stable at -20°C for 3 months after opening. It is recommended to freeze aliquots at -80°C for extended storage. Avoid repeated freeze-thaw cycles.

Shipping with dry ice.