2. 重组蛋白
  3. Receptor Proteins
  4. Cell Adhesion Molecules (CAMs)
  5. Cadherins
  6. Cadherin-13
  7. Cadherin-13 蛋白, Rat (HEK293, His)

Cadherin-13 蛋白, Rat (HEK293, His)

目录号: HY-P74362
产品使用指南

Cadherin-13 蛋白是钙粘蛋白家族的非典型成员，缺乏跨膜结构域，通过糖基磷脂酰肌醇锚定物锚定在质膜的外表面。它表现出对同质相互作用的偏好，促进相邻细胞之间的联系，并可能在细胞类型分选中发挥作用。Cadherin-13 可能充当神经细胞生长的负调节因子。此外，它可能充当信号传导受体，参与环境识别和细胞运动、增殖和表型的调节。Cadherin-13 蛋白, Rat (HEK293, His) 是重组的 Cadherin-13 蛋白，由 HEK293 表达，带有 C-His 标签。

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描述

Cadherin-13 Protein is an atypical member of the cadherin family, devoid of a transmembrane domain and anchored to the exterior surface of the plasma membrane via a glycosylphosphatidylinositol anchor. And it exhibits a preference for homophilic interactions, fostering connections between neighboring cells and potentially playing a role in cell type sorting. Cadherin-13 may act as negative regulators of neural cell growth. Moreover, it may act rather as a signalling receptor participating in recognition of the environment and regulation of cell motility, proliferation and phenotype. Cadherin-13 Protein, Rat (HEK293, His) is the recombinant rat-derived Cadherin-13 protein, expressed by HEK293 , with C-His labeled tag.
研究背景

Cadherin-13 是钙粘蛋白家族的非典型成员，缺乏跨膜结构域，通过糖基磷脂酰肌醇锚定物锚定在质膜的外表面。它表现出对同质相互作用的偏好，促进相邻细胞之间的联系，并可能在细胞类型分选中发挥作用。Cadherin-13 可能充当神经细胞生长的负调节因子。Cadherin-13 在神经和心血管系统 (内皮细胞和平滑肌细胞) 中高度表达。因此，它可能促进增殖性血管疾病的进展，例如动脉粥样硬化、再狭窄和肿瘤血管生成。此外，它可能充当信号传导受体，参与环境识别和细胞运动、增殖和表型的调节。PI3K/Akt/GSK3β 信号轴的 Cadherin-13 依赖性激活可保护内皮细胞免受氧化应激诱导的细胞凋亡[1][2]。
种属

Rat
表达系统

HEK293
标签

C-His
蛋白编号

Q8R490 (A22-A692)
基因 ID
蛋白结构
N-term
Cadherin-13 (A22-A692)
Accession # Q8R490
His
C-term
同用名
Cadherin-13; H-cadherin; T-cadherin; T-cad; CDH13
分子量

Approximately 117&95 kDa
纯度

Greater than 95% as determined by reducing SDS-PAGE.
内毒素含量

<1 EU/μg, determined by LAL method.
文件资料
产品使用指南 (1213 KB)

Cadherin-13 Protein, Rat (HEK293, His) 相关分类

Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

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The reconstitution calculator equation

Volume (to add to vial) = Mass (in vial) ÷ Desired Reconstitution Concentration

Volume (to add to vial) = Mass (in vial) ÷ Desired Reconstitution Concentration
= ÷

The dilution calculator equation

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

This equation is commonly abbreviated as: C1V1 = C2V2

浓度 (start) × 体积 (start) = 浓度 (final) × 体积 (final)
× = ×
C1   V1   C2   V2

The specific activity calculator equation

Specific Activity (Unit/mg) = 106 ÷ Biological Activity (ED50)

Specific Activity (Unit/mg) = 106 ÷ Biological Activity (ED50)
Unit/mg = 106 ÷ ng/mL

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