Carbonic Anhydrase 11 蛋白, Human (HEK293, His)

Carbonic Anhydrase 11 Protein, Human (HEK293, His) is an approximately 38.0 kDa carbonic anhydrase 11 protein with a His-flag. Carbonic anhydrases (CAs) are found in many organisms, in which they contribute to several important biological processes^[1].

碳酸酐酶 11 属于碳酸酐酶 (CA) 家族，可能参与细胞增殖和细胞转化。CA 是锌金属酶，可催化二氧化碳的可逆水合，从而参与多种生物和物理过程^[1]。
碳酸酐酶 11 存在于许多生物体中，其中它们有助于几个重要的生物过程。在小脑、大脑、肝脏、胃、小肠、结肠、肾脏和睾丸中可以观察到 CARP XI 的阳性信号^[2]。

Measured by its esterase activity that incubate at room temperature in kinetic mode for 5 minutes.The specific activity is 105.77 pmol/min/µg.

Human

HEK293

C-6*His

O75493 (V64-R328)

770  [NCBI]

HIGPAPDPEDWWSYKDNLQGNFVPGPPFWGLVNAAWSLCAVGKRQSPVDVELKRVLYDPFLPPLRLSTGGEKLRGTLYNTGRHVSFLPAPRPVVNVSGGPLLYSHRLSELRLLFGARDGAGSEHQINHQGFSAEVQLIHFNQELYGNFSAASRGPNGLAILSLFVNVASTSNPFLSRLLNRDTITRISYKNDAYFLQDLSLELLFPESFGFITYQGSLSTPPCSETVTWILIDRALNITSLQMHSLRLLSQNPPSQIFQSLSGNSRPLQPLAHRALRGNRDPRHPERRCRGPNYRLHVDGVPHGRHHHHHH

Approximately 38.0 kDa

Greater than 95% as determined by reducing SDS-PAGE.

溶液.

Supplied as a 0.2 μm filter solution of 20 mM PB,150 mM NaCl, pH 7.4.

<1 EU/μg, determined by LAL method.

Stored at -80°C for 1 year. It is stable at -20°C for 3 months after opening. It is recommended to freeze aliquots at -80°C for extended storage. Avoid repeated freeze-thaw cycles.

Shipping with dry ice.

• [1]. J A Loncaster, et al. Carbonic anhydrase (CA IX) expression, a potential new intrinsic marker of hypoxia: correlations with tumor oxygen measurements and prognosis in locally advanced carcinoma of the cervix. Cancer Res. 2001 Sep 1;61(17):6394-9.  [Content Brief]

  [2]. K Taniuchi, et al. Developmental expression of carbonic anhydrase-related proteins VIII, X, and XI in the human brain. Neuroscience. 2002;112(1):93-9.  [Content Brief]