Carbonic Anhydrase 2 蛋白, Mouse (His)

Carbonic Anhydrase 2 Protein is a member of the carbonic anhydrase isozyme family, responsible for catalyzing the reversible hydration of carbon dioxide. Mutations in CA2 are linked to osteopetrosis and renal tubular acidosis. The gene exhibits biased expression in various tissues, notably in the stomach and colon. CA2 plays vital role in the regulation of ion transport and pH balance and is involved in many biological processes. Carbonic Anhydrase 2 Protein, Mouse (His) is the recombinant mouse-derived Carbonic Anhydrase 2 protein, expressed by HEK293 , with C-His labeled tag. The total length of Carbonic Anhydrase 2 Protein, Mouse (His) is 259 a.a., with molecular weight of 30-35 kDa.

碳酸酐酶 2 (CA2) 是碳酸酐酶同工酶家族的成员，负责催化二氧化碳的可逆水合。这种酶的失调与骨硬化症和肾小管酸中毒等疾病有关。已鉴定出编码不同亚型的两种转录变体。除了在二氧化碳代谢中的基本作用外，该蛋白还在各种组织中表现出偏向表达，其中在胃和结肠以及其他八个组织中表达水平显著。它还可以将氰胺水合成尿素。CA2 对于骨吸收和破骨细胞分化至关重要。CA2 在离子传输和 pH 平衡的调节中起着至关重要的作用，并参与许多生物过程。此外，CA2下调促进HCC转移和侵袭。它可作为 HCC 转移和 EMT 的抑制剂，并与 HCC 患者良好的总生存 (OS) 相关^[1][2][3][4]。

Measured by its esterase activity. The specific activity is > 400 pmol/min/µg.

Mouse

HEK293

C-His

AAH55291 (S2-K260)

12349  [NCBI]

SHHWGYSKHNGPENWHKDFPIANGDRQSPVDIDTATAQHDPALQPLLISYDKAASKSIVNNGHSFNVEFDDSQDNAVLKGGPLSDSYRLIQFHFHWGSSDGQGSEHTVNKKKYAAELHLVHWNTKYGDFGKAVQQPDGLAVLGIFLKIGPASQGLQKVLEALHSIKTKGKRAAFANFDPCSLLPGNLDYWTYPGSLTTPPLLECVTWIVLREPITVSSEQMSHFRTLNFNEEGDAEEAMVDNWRPAQPLKNRKIKASFK

30-35 kDa

Greater than 95% as determined by reducing SDS-PAGE

溶液

Supplied as 0.22 μm filtered solution in PBS, pH 7.4.

<1 EU/μg, determined by LAL method.

N/A.

Stored at -80°C for 1 year. It is stable at -20°C for 3 months after opening. It is recommended to freeze aliquots at -80°C for extended storage. Avoid repeated freeze-thaw cycles.

Shipping with dry ice.