Cardiotrophin-1/CTF1 蛋白, Rat

Cardiotropin-1/CTF1 protein plays a key role in inducing cardiomyocyte hypertrophy in vitro. Its effects on myocardial development and enlargement are mediated through binding and activation of ILST/gp130 receptors. Cardiotrophin-1/CTF1 Protein, Rat is the recombinant rat-derived Cardiotrophin-1/CTF1 protein, expressed by E. coli , with tag free. The total length of Cardiotrophin-1/CTF1 Protein, Rat is 203 a.a., with molecular weight of ~21.4 kDa.

Cardiotropin-1/CTF1 蛋白发挥着关键作用，因为它在体外诱导心肌细胞肥大，强调其对与心肌发育和增大相关的细胞过程的影响。该蛋白的功能影响是通过其与 ILST/gp130 受体的结合和激活来介导的，揭示了 Cardiotropin-1/CTF1 发挥其作用的特定分子途径。这种相互作用强调了其在与心肌细胞反应相关的信号级联中的重要性，提供了对调节心肌肥大的调节机制的见解。

1.Fully biologically active when compared to standard. The ED50 as determined by a cell proliferation assay using human TF-1 cells is less than 0.5 ng/mL, corresponding to a specific activity of >2.0x10⁶ IU/mg.
2.Measured in a cell proliferation assay using CTF1 human erythroleukemic cells. The ED50 for this effect is 5.936 ng/mL, corresponding to a specific activity is 1.685×10^5 units/mg.

Rat

E. coli

Tag Free

Q63086 (M1-A203)

29201  [NCBI]

MSQREGSLEDHQTDSSFSFLPHLEAKIRQTHNLARLLTKYADQLLEEYVQQQGEPFGLPGFSPPRLPLAGLSGPAPSHAGLPVSERLRQDAAALSALPALLDAVRRRQAELNPRAPRLLRSLEDAARQVRALGAAVETVLAALGAAARGPVPEPVATSALFTSNSAAGVFSAKVLGLHVCGLYGEWVSRTEGDLGQLVPGGVA

Approximately 21.4 kDa

Greater than 95% as determined by reducing SDS-PAGE

无菌粉末

Lyophilized from a 0.2 μm solution of 50 mM Tris-HCL, 300 mM NaCl, pH 7.4.

<1 EU/μg, determined by LAL method.

It is not recommended to reconstitute to a concentration less than 100 μg/mL in sterile distilled water.

Stored at -20°C for 2 years. After reconstitution, it is stable at 4°C for 1 week or -20°C for longer (with carrier protein). It is recommended to freeze aliquots at -20°C or -80°C for extended storage.

Room temperature in continental US; may vary elsewhere.