CCN2/CTGF 蛋白, Mouse (GST)

CCN2/CTGF protein is a major connective tissue mitochondrial attractant secreted by vascular endothelial cells and promotes chondrocyte proliferation and differentiation. It mediates heparin- and divalent cation-dependent cell adhesion in various cell types, including fibroblasts, myofibroblasts, endothelial cells, and epithelial cells. CCN2/CTGF Protein, Mouse (GST) is the recombinant mouse-derived CCN2/CTGF protein, expressed by E. coli , with N-GST labeled tag. The total length of CCN2/CTGF Protein, Mouse (GST) is 319 a.a., with molecular weight of ~62 kDa.

CCN2/CTGF 蛋白是一种主要的结缔组织线粒体吸引剂，由血管内皮细胞分泌。它对促进软骨细胞的增殖和分化起着至关重要的作用。此外，CCN2/CTGF 介导各种细胞类型（包括成纤维细胞、肌成纤维细胞、内皮细胞和上皮细胞）中肝素和二价阳离子依赖性细胞粘附。此外，它还能增强成纤维细胞生长因子诱导的 DNA 合成。CCN2/CTGF 作为单体存在并与 TSKU 相互作用。

Measured by its ability to mediate Balb/3T3 mouse embryonic fibroblast cell adhesion. The ED₅₀ for this effect is 1.824 μg/mL.

Mouse

E. coli

N-GST

P29268 (Q26-Y344)

14219  [NCBI]

QDCSAQCQCAAEAAPHCPAGVSLVLDGCGCCRVCAKQLGELCTERDPCDPHKGLFCDFGSPANRKIGVCTAKDGAPCVFGGSVYRSGESFQSSCKYQCTCLDGAVGCVPLCSMDVRLPSPDCPFPRRVKLPGKCCEEWVCDEPKDRTAVGPALAAYRLEDTFGPDPTMMRANCLVQTTEWSACSKTCGMGISTRVTNDNTFCRLEKQSRLCMVRPCEADLEENIKKGKKCIRTPKIAKPVKFELSGCTSVKTYRAKFCGVCTDGRCCTPHRTTTLPVEFKCPDGEIMKKNMMFIKTCACHYNCPGDNDIFESLYYRKMY

Approximately 62 kDa

Greater than 90% as determined by reducing SDS-PAGE.

无菌粉末.

Lyophilized from a 0.2 μm solution of 10 mM Tris-HCl, 1 mM EDTA, 6% Trehalose, pH 8.0 or PBS, 6% Trehalose, pH 7.4.

<1 EU/μg, determined by LAL method.

It is not recommended to reconstitute to a concentration less than 100 μg/mL in ddH₂O.

Stored at -20°C for 2 years. After reconstitution, it is stable at 4°C for 1 week or -20°C for longer (with carrier protein). It is recommended to freeze aliquots at -20°C or -80°C for extended storage.

Room temperature in continental US; may vary elsewhere.