2. 重组蛋白
  3. Cytokines and Growth Factors Receptor Proteins
  4. Chemokine & Receptors G-Protein-Coupled Receptors (GPCRs)
  5. CC Chemokine Receptor Chemokine Receptor
  6. CCR8
  7. CCR8 蛋白, Human (P. pastoris, His)

CCR8 蛋白, Human (P. pastoris, His)

目录号: HY-P700543
产品使用指南

CCR8 蛋白-VLP 是 CCL1/SCYA1/I-309 的受体，可调节单核细胞趋化性和胸腺细胞系凋亡。它还与 CD4 一起作为 HIV-1 感染的替代辅助受体，促进病毒进入。与 CCL1 的相互作用凸显了它在介导细胞对该趋化因子的反应中的作用，这意味着在免疫和炎症过程中具有调节功能。CCR8 蛋白, Human (P. pastoris, His) 是重组的 CCR8 蛋白，由 P. pastoris 酵母表达，带有 C-Myc, C-6*His 标签。CCR8 蛋白, Human (P. pastoris, His) 全长 35 个氨基酸，分子量为 7.7 kDa。

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描述

CCR8 Protein-VLP, a receptor for CCL1/SCYA1/I-309, may regulate monocyte chemotaxis and thymic cell line apoptosis. It also acts as an alternative coreceptor with CD4 for HIV-1 infection, facilitating viral entry. The interaction with CCL1 highlights its role in mediating cellular responses to this chemokine, implying a regulatory function in immune and inflammatory processes. CCR8 Protein, Human (P. pastoris, His) is the recombinant human-derived CCR8 protein, expressed by P. pastoris, with C-Myc, C-6*His labeled tag. The total length of CCR8 Protein, Human (P. pastoris, His) is 35 a.a., with molecular weight of 7.7 kDa.
研究背景

CCR8 蛋白-VLP 作为趋化因子 CCL1/SCYA1/I-309 的受体，可能调节单核细胞趋化性和胸腺细胞系凋亡。它还与 CD4 一起作为 HIV-1 感染的替代辅助受体，这表明它参与促进病毒进入和感染。CCR8 和 CCL1 之间的相互作用强调了其在介导细胞对该趋化因子的反应中的作用，表明其在免疫和炎症过程中具有调节功能。
种属

Human
表达系统

P. pastoris
标签

C-Myc;C-6*His
蛋白编号

P51685 (M1-K35)
基因 ID
蛋白结构
N-term
CCR8 (M1-K35)
Accession # P51685
6*His-Myc
C-term
同用名
CCR8; chemokine (C-C motif) receptor 8; CMKBR8, CMKBRL2; C-C chemokine receptor type 8; CDw198; CKR L1; CY6; GPR CY6; TER1; CC chemokine receptor 8; chemokine receptor-like 1; chemokine (C-C) receptor 8; CC chemokine receptor CHEMR1; CC-chemokine receptor chemr1; chemokine (C-C) receptor-like 2; CCR-8; CKRL1; CMKBR8; GPRCY6; CMKBRL2; CC-CKR-8; MGC129966; MGC129973
氨基酸序列

MDYTLDLSVTTVTDYYYPDIFSSPCDAELIQTNGK

分子量

7.7 kDa
纯度

Greater than 90% as determined by reducing SDS-PAGE.
内毒素含量

<1 EU/μg, determined by LAL method.
文件资料
产品使用指南 (1213 KB)

CCR8 Protein, Human (P. pastoris, His) 相关分类

Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

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The reconstitution calculator equation

Volume (to add to vial) = Mass (in vial) ÷ Desired Reconstitution Concentration

Volume (to add to vial) = Mass (in vial) ÷ Desired Reconstitution Concentration
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The dilution calculator equation

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

This equation is commonly abbreviated as: C1V1 = C2V2

浓度 (start) × 体积 (start) = 浓度 (final) × 体积 (final)
× = ×
C1   V1   C2   V2

The specific activity calculator equation

Specific Activity (Unit/mg) = 106 ÷ Biological Activity (ED50)

Specific Activity (Unit/mg) = 106 ÷ Biological Activity (ED50)
Unit/mg = 106 ÷ ng/mL

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