CD163 蛋白, Human (Biotinylated, HEK293, His-Avi)

CD163 Protein, an acute phase-regulated receptor, crucially clears hemoglobin/haptoglobin complexes via endocytosis in macrophages, protecting tissues from potential oxidative damage. Beyond iron uptake, CD163 exhibits calcium- and pH-dependent binding preferences, with higher affinity for hemoglobin/haptoglobin complexes of HP*1F phenotype. It triggers intracellular signals, including tyrosine kinase-dependent calcium mobilization, inositol triphosphate production, and IL6 and CSF1 secretion. CD163 shedding produces a soluble form (sCD163) with potential anti-inflammatory properties, a valuable diagnostic parameter for monitoring macrophage activation in inflammatory conditions. CD163 Protein, Human (Biotinylated, HEK293, His-Avi) is the recombinant human-derived CD163 protein, expressed by HEK293, with C-Avi, C-His labeled tag. The total length of CD163 Protein, Human (Biotinylated, HEK293, His-Avi) is 1004 a.a., with molecular weight of 120-140 kDa.

CD163 是一种急性期调节受体，关键参与巨噬细胞对血红蛋白/触珠蛋白复合物的清除和内吞，从而保护组织免受游离血红蛋白引起的潜在氧化损伤。除了通过血红蛋白/结合珠蛋白的内吞作用在铁吸收和再循环中发挥作用之外，CD163 还以钙依赖性和 pH 依赖性方式与这些复合物结合。值得注意的是，与 HP*1S 表型的血红蛋白和二聚体触珠蛋白的复合物相比，它对 HP*1F 表型的血红蛋白和多聚体触珠蛋白的复合物表现出更高的亲和力。CD163 诱导一系列细胞内信号，涉及酪氨酸激酶依赖性钙动员、三磷酸肌醇产生以及 IL6 和 CSF1 的分泌。尤其是同工型 3，在细胞中表达时，显示出增强的配体内吞作用和表面表达。CD163 的脱落产生具有潜在抗炎特性的可溶形式 (sCD163)，可作为监测炎症条件下巨噬细胞活化的有价值的诊断参数。

Human

HEK293

C-Avi;C-His

Q86VB7-1 (S42-S1045)

9332  [NCBI]

120-140 kDa

Greater than 95% as determined by reducing SDS-PAGE.

<1 EU/μg, determined by LAL method.