CD1E-B2M Heterodimer 蛋白, Cynomolgus (HEK293, His)

TREM-2 Protein is an immune receptor expressed on immune and non-immune cells. It is an anti-inflammatory molecule and considered a marker for microglia activation^[1]. CD1E-B2M Heterodimer Protein, Cynomolgus (HEK293, His) is a recombinant protein dimer complex containing cynomolgus-derived CD1E-B2M Heterodimer protein, expressed by HEK293 , with N-His labeled tag.

骨髓细胞 2 上表达的触发受体 (TREM-2) 是一种在免疫和非免疫细胞上表达的免疫受体，在神经退行性疾病中更常被研究，并被认为是小胶质细胞激活的标志物。在传染病中，该受体最初被认为是一种抗炎分子，可以抵抗 TREM-1 引发的炎症。目前，TREM-2 与感染刺激反应的多个方面相关，包括诱导细菌吞噬和清除、抑制加剧的促炎反应、诱导 M2 分化和激活 Th1 淋巴细胞，以及病毒感染后的神经损伤^[1]。

Immobilized Cynomolgus CD1E-B2M Heterodimer at 2 μg/mL (100 μL/well) can bind Anti-B2M Antibody. The ED₅₀ for this effect is 83.24 ng/mL.

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  Immobilized Cynomolgus CD1E-B2M Heterodimer at 2 μg/mL (100 μL/well) can bind Anti-B2M Antibody. The ED₅₀ for this effect is 83.24 ng/mL.

Cynomolgus

HEK293

N-6*His

EHH50396 (E32-G303)&Q6V7J5 (I21-M119)

712428  [NCBI]

Approximately 34-40&12 kDa

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  Greater than 95% as determined by reducing SDS-PAGE.

无菌粉末

Lyophilized from a 0.2 μm filtered solution of PBS, pH 7.4. Normally 5 % - 8 % trehalose, mannitol and 0.01% Tween 80 are added as protectants before lyophilization.

<1 EU/μg, determined by LAL method.

It is not recommended to reconstitute to a concentration less than 100 μg/mL in ddH₂O.

Stored at -20°C for 2 years. After reconstitution, it is stable at 4°C for 1 week or -20°C for longer (with carrier protein). It is recommended to freeze aliquots at -20°C or -80°C for extended storage.

Room temperature in continental US; may vary elsewhere.