CD2 蛋白, Cynomolgus/Rhesus Macaque (HEK293, C-His)

CD2 Protein mediates T-cell adhesion to other cell types by interacting with CD58 (LFA-3) and CD48/BCM1. Implicated in T-cell triggering, its cytoplasmic domain has signaling functions. CD2 also interacts with CD2AP and PSTPIP1. Moreover, its interaction with FCGR3A modulates NK cell activation and cytotoxicity. CD2 Protein, Cynomolgus/Rhesus Macaque (HEK293, C-His) is the recombinant cynomolgus-derived CD2 protein, expressed by HEK293 , with C-6*His labeled tag.

CD2 是一种细胞表面糖蛋白，通过与淋巴细胞功能相关抗原 CD58 (LFA-3) 和 CD48/BCM1 相互作用，在介导 T 细胞和各种细胞类型之间的粘附方面发挥着至关重要的作用。除了其粘附功能外，CD2 还参与触发 T 细胞反应，其胞质结构域在信号传导通路中发挥作用。该蛋白与 CD48、CD58 (LFA-3)、CD2AP 和 PSTPIP1 相互作用，形成复杂的分子相互作用网络。此外，CD2 和 FCGR3A 之间的相互作用可调节 NK 细胞活化和细胞毒性，凸显其在免疫细胞功能中的多种参与。

Measured by the ability of the immobilized protein to support the adhesion of Jurkat human T-lymphocyte leukemia cells. The ED₅₀ this effect is 0.571 ng/mL, corresponding to a specific activity is 1.7513×10⁶ units/mg.

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  Measured by the ability of the immobilized protein to support the adhesion of Jurkat human T-lymphocyte leukemia cells. The ED₅₀ this effect is 0.571 ng/mL, corresponding to a specific activity is 1.7513×10⁶ units/mg.

Rhesus Macaque; Cynomolgus

HEK293

C-6*His

Q6SZ61/NP_001182402.1 (K25-D209)

102120798  [NCBI]/677855

KEIRNALETWGALGQDIDLDIPSFQMSDDIDDIRWEKTSDKKKIAQFRKEKETFEEKDAYKLFKNGTLKIKHLKIHDQDSYKVSIYDTKGKNVLEKTFDLKIQERVSEPKISWTCINTTLTCEVMNGTDPELNLYQDGKHVKLSQRVITHKWTTSLSAKFKCTAGNKVSKESRMETVSCPEKGLD

Approximately 33.91 kDa

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  Greater than 90% as determined by reducing SDS-PAGE.

无菌粉末.

Lyophilized from a 0.2 μm filtered solution of 20 mM PB, 150 mM NaCl, pH 7.4.

<1 EU/μg, determined by LAL method.

It is not recommended to reconstitute to a concentration less than 100 μg/mL in ddH₂O. For long term storage it is recommended to add a carrier protein (0.1% BSA, 5% HSA, 10% FBS or 5% Trehalose).

Stored at -20°C for 2 years. After reconstitution, it is stable at 4°C for 1 week or -20°C for longer (with carrier protein). It is recommended to freeze aliquots at -20°C or -80°C for extended storage.

Room temperature in continental US; may vary elsewhere.