CD20/MS4A1 蛋白, Mouse (P.pastoris, His)

CD20/MS4A1 protein regulates cellular calcium influx, essential for B-lymphocyte development, differentiation, and activation. It activates store-operated calcium channels, allowing calcium influx through B-cell receptor/BCR activation. CD20/MS4A1 protein forms homotetramers and interacts with cell surface IgM chains, the antigen-binding parts of the BCR. CD20/MS4A1 Protein, Mouse (P.pastoris, His) is the recombinant mouse-derived CD20/MS4A1 protein, expressed by P. pastoris , with N-6*His labeled tag. The total length of CD20/MS4A1 Protein, Mouse (P.pastoris, His) is 181 a.a., with molecular weight (glycosylation form) of ~33 kDa.

CD20/MS4A1 蛋白是一种 B 淋巴细胞特异性膜蛋白，在调节细胞钙内流方面发挥着至关重要的作用，这对于 B 淋巴细胞的发育、分化和激活是必需的。它作为钙库操纵 (SOC) 通道的一个组成部分发挥作用，在 B 细胞受体/BCR 激活后促进钙流入。CD20/MS4A1 蛋白形成同源四聚体，并与细胞表面 IgM 的重链和轻链相互作用，IgM 是 BCR 的抗原结合成分。

Mouse

P. pastoris

N-6*His

P19437 (V111-P291)

12482  [NCBI]

VIMSSLSLFAAISGIILSIMDILNMTLSHFLKMRRLELIQTSKPYVDIYDCEPSNSSEKNSPSTQYCNSIQSVFLGILSAMLISAFFQKLVTAGIVENEWKRMCTRSKSNVVLLSAGEKNEQTIKMKEEIIELSGVSSQPKNEEEIEIIPVQEEEEEEAEINFPAPPQEQESLPVENEIAP

Approximately 33 kDa.The reducing (R) protein migrat es as 33 kDa in SDS-PAGE may be due to glycosylation.

Greater than 90% as determined by reducing SDS-PAGE.

无菌粉末

Lyophilized after extensive dialysis against solution in 20 mM Tris-HCl, 0.5 M NaCl, 6% Trehalose, pH 8.0 or PBS, 6% Trehalose, pH 7.4.

<1 EU/μg, determined by LAL method.

It is not recommended to reconstitute to a concentration less than 100 μg/mL in ddH₂O.

Stored at -20°C for 2 years. After reconstitution, it is stable at 4°C for 1 week or -20°C for longer (with carrier protein). It is recommended to freeze aliquots at -20°C or -80°C for extended storage.

Room temperature in continental US; may vary elsewhere.