CD200 蛋白, Rhesus Macaque (HEK293, His)

CD200 protein functions as a costimulator of T-cell proliferation and is implicated in the potential regulation of myeloid cell activity across various tissues. Through their N-terminal Ig-like domains, CD200 interacts with CD200R1, establishing a molecular interaction that likely contributes to the modulation of immune responses and cellular activities. CD200 Protein, Rhesus Macaque (HEK293, His) is the recombinant Rhesus Macaque-derived CD200 protein, expressed by HEK293 , with C-His labeled tag. The total length of CD200 Protein, Rhesus Macaque (HEK293, His) is 202 a.a., with molecular weight of ~24 KDa.

CD200 蛋白在免疫调节中发挥着关键作用，作为促进 T 细胞增殖的共刺激分子。此外，正如基于相似性的推论所表明的，CD200 参与了跨不同组织的骨髓细胞活性的潜在调节。CD200 与其受体 CD200R1 之间的相互作用是通过它们各自的 N 端 Ig 样结构域促进的。这种相互作用可能有助于参与免疫反应和骨髓细胞功能的调节过程。CD200 与 CD200R1 的结合强调了其在介导免疫细胞通讯和稳态方面的重要性，强调了其作为免疫调节关键参与者的潜力。

Measured by its binding ability in a functional ELISA. When Recombinant Human CD200 R1 is immobilized at 2 µg/mL (100 µL/well) can bind Rhesus Macaque CD200. The ED₅₀ for this effect is 0.8551ng/mL.

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  Measured by its binding ability in a functional ELISA. When Recombinant Human CD200 R1 is immobilized at 2 µg/mL (100 µL/well) can bind Rhesus Macaque CD200. The ED₅₀ for this effect is 0.8551 ng/mL.

Rhesus Macaque

HEK293

C-His

H9EXH3 (Q31-G232)

708110  [NCBI]

QVQVVTQDEREQLYTPASLRCSLQNAQEVLIVTWQKKKAVSPENMVTFSENHGVVIQPAYKDKINITQLGLQNTTITFWNITLEDEGCYMCLFNTFGSGKISGTACLTVYVQPIVSLHYKYSEDHLNITCSATARPAPMIFWKVPRSGFENSTVTLSHPNGTTSVTSILHVKDPKNQVGKEVICQVLHLGTVTDFKQTFDKG

The protein has a predicted molecular mass of approximately 22.8 kDa. The protein migrates as an approximately 40-49 kDa band under reducing SDS-PAGE due to glycosylation.

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  Greater than 95% as determined by reducing SDS-PAGE.

无菌粉末

Lyophilized from a 0.2 μm filtered solution of PBS, pH 7.4.

<1 EU/μg, determined by LAL method.

It is not recommended to reconstitute to a concentration less than 100 μg/mL in ddH₂O. For long term storage it is recommended to add a carrier protein (0.1% BSA, 5% HSA, 10% FBS or 5% Trehalose).

Stored at -20°C for 2 years. After reconstitution, it is stable at 4°C for 1 week or -20°C for longer (with carrier protein). It is recommended to freeze aliquots at -20°C or -80°C for extended storage.

Room temperature in continental US; may vary elsewhere.