1. 重组蛋白
  2. CD Antigens Enzymes & Regulators
  3. T Cell CD Proteins Macrophage CD Proteins Stem Cell CD Proteins Epithelial cell CD Proteins Hydrolases (EC 3)
  4. DPP IV/CD26
  5. CD26/Dipeptidyl Peptidase 4 蛋白, Cynomolgus (HEK293)

CD26/Dipeptidyl Peptidase 4 蛋白, Cynomolgus (HEK293)

目录号: HY-P76875
产品使用指南

CD26/Dipeptidyl Peptidase 4 蛋白是一种丝氨酸膜锚定的外肽酶,属于二肽基肽酶 (DPP) 家族,广泛表达于多种组织和许多细胞中。CD26/Dipeptidyl Peptidase 4 蛋白, Cynomolgus (HEK293) 是重组的 CD26/二肽基肽酶 4 蛋白,由 HEK293 表达,不带标签。CD26/Dipeptidyl Peptidase 4 蛋白, Cynomolgus (HEK293) 全长 733 个氨基酸,分子量为 92-102 kDa。

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描述

CD26/Dipeptidyl Peptidase 4 Protein is a serine membrane anchored exopeptidase, belonging to dipeptidyl peptidase (DPP) family. CD26/Dipeptidyl Peptidase 4 Protein is widely expressed in a variety of tissues and many cells[1]. CD26/Dipeptidyl Peptidase 4 Protein, Cynomolgus (HEK293) is the recombinant cynomolgus-derived CD26/Dipeptidyl Peptidase 4 protein, expressed by HEK293 , with tag free. The total length of CD26/Dipeptidyl Peptidase 4 Protein, Cynomolgus (HEK293) is 733 a.a., with molecular weight of 92-102 kDa.

研究背景

二肽基肽酶 4 (DPP4),也称为 T 细胞表面抗原 CD26,是人体中普遍存在的酶。广泛表达于多种组织(肺、脑、胰腺、肾、血管、前列腺、子宫、胸腺、淋巴结和脾)和多种细胞(上皮细胞、内皮细胞、免疫细胞),尤其是高表达 在肾脏和小肠。它是一种跨膜糖蛋白,由766个氨基酸组成,相对分子量为110kDa。其基本结构主要包括:胞内N端区、跨膜区和胞外区。胞外部分由柔性杆、糖基化丰富区(抗CD26抗体、腺苷脱氨酶(ADA)和caveolin-1的结合区)、半胱氨酸丰富区(胶原蛋白和纤连蛋白的结合区)和催化区组成 催化三联体 Ser630、Asp708 和 His740。其中,共翻译核心 N-糖基化与 DPP4 折叠和稳定性显着相关,而 N-末端唾液酸化似乎调节更多的病理生理过程。高唾液酸化的 DDP4 与 HIV 和类风湿性关节炎的发生有关,而唾液酸化不足的 DPP4 则与肺癌有关[1]

种属

Cynomolgus

表达系统

HEK293

标签

Tag Free

蛋白编号

F6VRB0 (D34-P766)

基因 ID
蛋白结构
N-term
CD26 (D34-P766)
Accession # F6VRB0
C-term
同用名
Dipeptidyl peptidase 4; ADABP; ADCP-2; DPP IV; TP103; CD26; DPP4
分子量

92-102 kDa

纯度

Greater than 95% as determined by reducing SDS-PAGE

内毒素含量

<1 EU/μg, determined by LAL method.

文件资料
Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

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The reconstitution calculator equation

Volume (to add to vial) = Mass (in vial) ÷ Desired Reconstitution Concentration

Volume (to add to vial) = Mass (in vial) ÷ Desired Reconstitution Concentration
= ÷

The dilution calculator equation

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

This equation is commonly abbreviated as: C1V1 = C2V2

浓度 (start) × 体积 (start) = 浓度 (final) × 体积 (final)
× = ×
C1   V1   C2   V2

The specific activity calculator equation

Specific Activity (Unit/mg) = 106 ÷ Biological Activity (ED50)

Specific Activity (Unit/mg) = 106 ÷ Biological Activity (ED50)
Unit/mg = 106 ÷ ng/mL

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产品名称:
CD26/Dipeptidyl Peptidase 4 Protein, Cynomolgus (HEK293)
目录号:
HY-P76875
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