2. 重组蛋白
  3. Cytokines and Growth Factors Immune Checkpoint Proteins CD Antigens Biotinylated Proteins
  4. TNF Superfamily Stimulatory Immune Checkpoint Molecules T Cell CD Proteins B Cell CD Proteins NK Cell CD Proteins Macrophage CD Proteins Stem Cell CD Proteins
  5. TNF Receptor Superfamily CD27
  6. CD27/TNFRSF7 蛋白, Human (Biotinylated, HEK293, Fc-Avi)

CD27/TNFRSF7 蛋白, Human (Biotinylated, HEK293, Fc-Avi)

目录号: HY-P75630
产品使用指南

CD27/TNFRSF7 蛋白是 CD70/CD27L 的受体，可以确保活化 T 细胞的存活，表明它在免疫反应中发挥着至关重要的作用。它与 SIVA1 的关联表明在细胞凋亡途径中具有调节功能。CD27/TNFRSF7 蛋白, Human (Biotinylated, HEK293, Fc-Avi) 是重组的 CD27/TNFRSF7 蛋白，由 HEK293 表达，带有 C-Avi, C-hFc 标签。CD27/TNFRSF7 蛋白, Human (Biotinylated, HEK293, Fc-Avi) 全长 173 个氨基酸，分子量约为 ~47.8 kDa。

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描述

The CD27/TNFRSF7 protein is a receptor for CD70/CD27L and may ensure the survival of activated T cells, suggesting that it plays a crucial role in immune responses. Its association with SIVA1 suggests a regulatory function in the apoptotic pathway. CD27/TNFRSF7 Protein, Human (Biotinylated, HEK293, Fc-Avi) is the recombinant human-derived CD27/TNFRSF7 protein, expressed by HEK293 , with C-Avi, C-hFc labeled tag. The total length of CD27/TNFRSF7 Protein, Human (Biotinylated, HEK293, Fc-Avi) is 173 a.a., with molecular weight of ~47.8 kDa.
研究背景

CD27/TNFRSF7 蛋白作为 CD70/CD27L 的受体，可能在活化 T 细胞的存活中发挥关键作用，这表明它参与免疫反应。此外，它可能通过与 SIVA1 的关联而促进细胞凋亡，这表明它在程序性细胞死亡途径中具有调节功能。CD27/TNFRSF7 以同二聚体形式存在，与 SIVA1 和 TRAF2 等关键蛋白相互作用，表明其参与复杂的信号级联反应。CD27/TNFRSF7 在 T 细胞存活和凋亡中的多方面作用强调了其在免疫调节中的重要性，并强调了其作为旨在调节免疫反应的治疗干预目标的潜力。
种属

Human
表达系统

HEK293
标签

C-Avi;C-hFc
蛋白编号

P26842 (A20-I192)
基因 ID

939  [NCBI]
蛋白结构
N-term
CD27 (A20-I192)
Accession # P26842
hFc-Avi
C-term
同用名
CD27 antigen; T cell activation antigen CD27; T14; TNFRSF7
分子量

Approximately 47.8 kDa
纯度

Greater than 95% as determined by reducing SDS-PAGE.
内毒素含量

<1 EU/μg, determined by LAL method.
文件资料
产品使用指南 (1213 KB)

CD27/TNFRSF7 Protein, Human (Biotinylated, HEK293, Fc-Avi) 相关分类

Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

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The reconstitution calculator equation

Volume (to add to vial) = Mass (in vial) ÷ Desired Reconstitution Concentration

Volume (to add to vial) = Mass (in vial) ÷ Desired Reconstitution Concentration
= ÷

The dilution calculator equation

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

This equation is commonly abbreviated as: C1V1 = C2V2

浓度 (start) × 体积 (start) = 浓度 (final) × 体积 (final)
× = ×
C1   V1   C2   V2

The specific activity calculator equation

Specific Activity (Unit/mg) = 106 ÷ Biological Activity (ED50)

Specific Activity (Unit/mg) = 106 ÷ Biological Activity (ED50)
Unit/mg = 106 ÷ ng/mL

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