CD276/B7-H3 蛋白, Rat (HEK293, His)

CD276/B7-H3 Protein regulates T-cell-mediated immune responses and transplant rejection. It also promotes bone formation, functioning at the bone-immune interface. Additionally, it activates immune responses against tumors, eliminating them through natural killer cells and CD8 T-cells. Its interaction with TREML2 enhances T-cell activation, highlighting its role in immune regulation. CD276/B7-H3 Protein, Rat (HEK293, His) is the recombinant rat-derived CD276/B7-H3 protein, expressed by HEK293 , with C-His labeled tag.

CD276/B7-H3 是一种多方面的蛋白质，对 T 细胞介导的免疫反应以及急性和慢性移植排斥的进展发挥调节影响。除了其免疫调节作用外，它还可能对骨形成做出积极贡献，表现出骨-免疫界面的双重功能。此外，CD276 通过激活获得性和先天性免疫反应，成为抗肿瘤免疫的关键参与者，从而通过自然杀伤细胞和 CD8 T 细胞依赖性机制消除肿瘤细胞。值得注意的是，它与 TREML2 的相互作用增强了 T 细胞的激活，进一步强调了它在免疫调节中的复杂参与。

Measured by its binding ability in a functional ELISA. Immobilized Rat B7-H3, at 2μg/mL (100μL/well) can bind Anti-B7-H3 antibody. The ED₅₀ for this effect is 17.7 ng/mL.

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  Measured by its binding ability in a functional ELISA. Immobilized Rat B7-H3, at 2 μg/mL (100 μL/well) can bind Anti-B7-H3 antibody. The ED₅₀ for this effect is 17.7 ng/mL.

Rat

HEK293

C-6*His

Q7TPB4 (V29-F244)

315716  [NCBI]

VEVQVSEDPVVALVDTDATLRCSFSPEPGFSLRQLNLIWQLTDTKQLVHSFTEGRDQGSAYANRTALFPDLLVQGNASLRLQRVRVTDEGSYTCFVSIQDFDSAAVSLQVAAPYSKPSMTLEPNKDLRPGDMVTITCSSYQGYPEAEVFWKDGQGLPLTGNVTTSQMANERGLFDVHSVLRVVLGANGTYSCLVRNPVLQQDAHGSVTITGQPMTF

Approximately 34-43 kDa due to the glycosylation.

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  Greater than 95% as determined by reducing SDS-PAGE.

无菌粉末

Lyophilized from a 0.2 μm filtered solution of PBS, pH 7.4.

<1 EU/μg, determined by LAL method.

It is not recommended to reconstitute to a concentration less than 100 μg/mL in ddH₂O. For long term storage it is recommended to add a carrier protein (0.1% BSA, 5% HSA, 10% FBS or 5% Trehalose).

Stored at -20°C for 2 years. After reconstitution, it is stable at 4°C for 1 week or -20°C for longer (with carrier protein). It is recommended to freeze aliquots at -20°C or -80°C for extended storage.

Room temperature in continental US; may vary elsewhere.