CD299 蛋白, Human (HEK293, Fc)

The CD299 protein is an important C-type lectin that plays a role in cell adhesion and pathogen recognition. It can identify pathogens such as Mycobacterium tuberculosis, Ebola virus, hepatitis C, HIV-1, influenza A, West Nile virus and SARS-CoV. CD299 Protein, Human (HEK293, Fc) is the recombinant human-derived CD299 protein, expressed by HEK293 , with N-hFc labeled tag. The total length of CD299 Protein, Human (HEK293, Fc) is 322 a.a., with molecular weight (glycosylation form) of 65.83 kDa.

CD299 是一种编码 C 型凝集素的基因，在细胞粘附和病原体识别中发挥着至关重要的作用。该受体具有广泛的特异性，可识别对公共卫生具有重大影响的多种病原体，包括结核分枝杆菌、埃博拉病毒、丙型肝炎、HIV-1、甲型流感、西尼罗河病毒和 SARS-CoV 急性呼吸综合征冠状病毒。该蛋白质结构包含四个不同的结构域：C 端碳水化合物识别结构域、可变长度的柔性串联重复颈结构域、跨膜区和参与内化的 N 端细胞质结构域。CD299 与其邻近基因 CD209（也称为 DC-SIGN）具有密切的序列和功能相似性，尽管它们在病毒识别和表达模式方面有所不同。CD299 在肝脏、淋巴结和胎盘的内皮细胞中表现出高表达。值得注意的是，串联重复颈结构域的多态性与对 SARS 感染的抵抗力有关。由于在肝脏 (RPKM 15.4) 和淋巴结 (RPKM 9.8) 等组织中观察到了偏向表达，CD299 在免疫反应和病原体防御中发挥着关键作用。

Human

HEK293

N-hFc

Q9H2X3-1/NP_055072.3 (S78-E399)

10332  [NCBI]

SLSQEQSEQDAIYQNLTQLKAAVGELSEKSKLQEIYQELTQLKAAVGELPEKSKLQEIYQELTRLKAAVGELPEKSKLQEIYQELTRLKAAVGELPEKSKLQEIYQELTRLKAAVGELPEKSKLQEIYQELTELKAAVGELPEKSKLQEIYQELTQLKAAVGELPDQSKQQQIYQELTDLKTAFERLCRHCPKDWTFFQGNCYFMSNSQRNWHDSVTACQEVRAQLVVIKTAEEQNFLQLQTSRSNRFSWMGLSDLNQEGTWQWVDGSPLSPSFQRYWNSGEPNNSGNEDCAEFSGSGWNDNRCDVDNYWICKKPAACFRDE

65.83 KDa, due to glycosylation

Greater than 90% as determined by reducing SDS-PAGE

溶液.

Supplied as a 0.2 μm filtered solution of PBS, pH 7.4.

<1 EU/μg, determined by LAL method.

N/A.

Stored at -80°C for 1 year. It is stable at -20°C for 3 months after opening. It is recommended to freeze aliquots at -80°C for extended storage. Avoid repeated freeze-thaw cycles.

Shipping with dry ice.