CD3 epsilon 蛋白, Rhesus Macaque (HEK293, His)

CD3 epsilon Protein, a vital component of the TCR-CD3 complex on T-lymphocytes, is pivotal for adaptive immune responses. CD3E is crucial for proper T-cell development and contributes to TCR-CD3 complex internalization and down-regulation^[1]. CD3 epsilon Protein, Rhesus Macaque (HEK293, His) is the recombinant Rhesus Macaque-derived CD3 epsilon protein, expressed by HEK293 , with C-His labeled tag.

CD3 epsilon 蛋白是 T 淋巴细胞上 TCR-CD3 复合物的重要组成部分，对于适应性免疫反应至关重要。当抗原呈递细胞 (APC) 激活 T 细胞受体 (TCR) 时，TCR 介导的信号通过 CD3 链 CD3D、CD3E、CD3G 和 CD3Z 跨细胞膜传递。CD3E 对于 T 细胞的正常发育至关重要，并有助于 TCR-CD3 复合物的内化和下调。CD3D/CD3E 和 CD3G/CD3E 异二聚体与 TCRα 和 TCRβ 形成三聚体，完成 TCR-CD3 复合物。CD3E 与 CD6 和 NCK1 的相互作用凸显了其在 T 细胞反应中的多方面作用^[1]。

Rhesus Macaque

HEK293

C-His

XP_001097204.1 (Q22-D117)

699467  [NCBI]

Approximately 12.3 kDa.

Greater than 95% as determined by reducing SDS-PAGE

无菌粉末.

Lyophilized from a 0.2 μm filtered solution of PBS, pH 7.4. Normally 5 % - 8 % trehalose, mannitol and 0.01% Tween 80 are added as protectants before lyophilization.

<1 EU/μg, determined by LAL method.

It is not recommended to reconstitute to a concentration less than 100 μg/mL in ddH₂O.

Stored at -20°C for 2 years. After reconstitution, it is stable at 4°C for 1 week or -20°C for longer (with carrier protein). It is recommended to freeze aliquots at -20°C or -80°C for extended storage.

Room temperature in continental US; may vary elsewhere.