1. 重组蛋白
  2. CD Antigens
  3. Platelet CD Proteins
  4. CD42c/GP-Ib beta
  5. CD42c/GP1BB 蛋白, Mouse (HEK293, Fc)

CD42c/GP1BB 蛋白, Mouse (HEK293, Fc)

目录号: HY-P77686
产品使用指南

血小板上的 CD42c/GP1BB 蛋白通过与锚定的冯维勒布兰德因子结合,主动形成栓塞。这涉及二硫键连接的 GP-Ib 亚基,形成 GP-Ib 异二聚体。GP-IX 通过非共价连接增强受体稳定性。从分子角度来看,CD42c 与 TRAF4 的相似性表明其在调节血小板功能的调节网络中发挥作用。CD42c/GP1BB 蛋白, Mouse (HEK293, Fc) 是重组的 CD42c/GP1BB 蛋白,由 HEK293 表达,带有 C-hFc 标签。CD42c/GP1BB 蛋白, Mouse (HEK293, Fc) 全长 121 个氨基酸,分子量为 46-50 kDa。

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描述

CD42c/GP1BB protein on platelets actively forms plugs by engaging with anchored von Willebrand factor. This involves disulfide-linked GP-Ib subunits, forming the GP-Ib heterodimer. GP-IX enhances receptor stability through a non-covalent linkage. Molecularly, CD42c's similarity to TRAF4 suggests a role in regulating the platelet function's regulatory network. CD42c/GP1BB Protein, Mouse (HEK293, Fc) is the recombinant mouse-derived CD42c/GP1BB protein, expressed by HEK293 , with C-hFc labeled tag. The total length of CD42c/GP1BB Protein, Mouse (HEK293, Fc) is 121 a.a., with molecular weight of 46-50 kDa.

研究背景

CD42c 是血小板上发现的一种表面膜蛋白,通过与已经锚定在内皮下的血管性血友病因子 (vWF) 结合,积极促进血小板栓塞的形成。该过程涉及两个 GP-Ib β 亚基与一个 GP-Ib α 亚基通过二硫键连接,共同形成 GP-Ib 异二聚体。此外,GP-IX 通过非共价连接与 GP-Ib 异二聚体错综复杂地结合,增强了该血小板表面受体的整体稳定性和功能性。在分子相互作用中,CD42c 与肿瘤坏死因子受体相关因子 4 (TRAF4) 的关联表现出相似性,表明其在控制血小板功能的调节网络中发挥作用。

种属

Mouse

表达系统

HEK293

标签

C-hFc

蛋白编号

P56400 (P27-C147)

基因 ID
蛋白结构
N-term
Gp1bb (P27-C147)
Accession # P56400
hFc
C-term
同用名
GP-Ib beta; GPIb-beta; GPIbB; Gp1bb; BDPLT1; BS; CD42c; GP1BB; GPIbb; GPIbbeta
分子量

46-50 kDa

纯度

Greater than 95% as determined by Tris-Bis PAGE.

内毒素含量

<1 EU/μg, determined by LAL method.

文件资料

CD42c/GP1BB Protein, Mouse (HEK293, Fc) 相关分类

Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

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  • 重组蛋白稀释计算器

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The reconstitution calculator equation

Volume (to add to vial) = Mass (in vial) ÷ Desired Reconstitution Concentration

Volume (to add to vial) = Mass (in vial) ÷ Desired Reconstitution Concentration
= ÷

The dilution calculator equation

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

This equation is commonly abbreviated as: C1V1 = C2V2

浓度 (start) × 体积 (start) = 浓度 (final) × 体积 (final)
× = ×
C1   V1   C2   V2

The specific activity calculator equation

Specific Activity (Unit/mg) = 106 ÷ Biological Activity (ED50)

Specific Activity (Unit/mg) = 106 ÷ Biological Activity (ED50)
Unit/mg = 106 ÷ ng/mL

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产品名称:
CD42c/GP1BB Protein, Mouse (HEK293, Fc)
目录号:
HY-P77686
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