CD7 蛋白, Rat (HEK293, Fc)

The CD7 Protein is a member of the immunoglobulin superfamily expressed in thymocytes and mature T cells. CD7 Protein can activate the PI3K signaling pathway involved in the activation of T and NK cells. CD7 Protein is a key factor in the treatment of T-cell acute lymphoblastic leukemia (T-ALL) and T-lymphoma. CD7 Protein, Rat (HEK293, Fc) is the recombinant rat-derived CD7 protein, expressed by HEK293 , with C-hFc labeled tag.

CD7 蛋白是免疫球蛋白超家族的一种跨膜蛋白，存在于胸腺细胞和成熟的 T 细胞中。在早期淋巴细胞发育过程中，它在 T 细胞相互作用和 T 细胞/ B 细胞相互作用中起重要作用。CD7 可激活 PI3K 信号通路参与 T 和 NK 细胞的活化。CD7 广泛分布于肿瘤，被认为是治疗 T 细胞急性淋巴细胞白血病 (T-ALL) 和 T-淋巴瘤的关键因子。

Measured by its binding ability in a functional ELISA. Immobilized Rat CD7, at 0.5μg/mL (100μL/well) can bind Anti-CD7 antibody. The ED₅₀ for this effect is 2.645μg /mL.

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  Measured by its binding ability in a functional ELISA. Immobilized Rat CD7, at 0.5μg/mL (100μL/well) can bind Anti-CD7 antibody. The ED₅₀ for this effect is 2.645μg /mL.

Rat

HEK293

C-hFc

B2RZ54 (Q23-P149)

303747  [NCBI]

QEVHQSPRVVIASEGESINITCSTRGDLEGLIMKRIWPQASNVIYFEDELEPTVDSAFSGRINFSGSQKNLTIIMSLLQEADTGAYTCEAVRKVSVHGLFTTVVVKEKLSHEAYRSQEPLQTSVSLP

Approximately 45-60 kDa due to the glycosylation.

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  Greater than 95% as determined by reducing SDS-PAGE.

无菌粉末

Lyophilized from a 0.2 μm filtered solution of PBS, pH 7.4.

<1 EU/μg, determined by LAL method.

It is not recommended to reconstitute to a concentration less than 100 μg/mL in ddH₂O. For long term storage it is recommended to add a carrier protein (0.1% BSA, 5% HSA, 10% FBS or 5% Trehalose).

Stored at -20°C for 2 years. After reconstitution, it is stable at 4°C for 1 week or -20°C for longer (with carrier protein). It is recommended to freeze aliquots at -20°C or -80°C for extended storage.

Room temperature in continental US; may vary elsewhere.