CD79B 蛋白, Mouse (HEK293, Fc)

CD79B protein, together with CD79A, initiates the B-cell antigen receptor complex (BCR) signaling cascade, which is critical for complex internalization and transport to late endosomes, promoting antigen presentation. CD79B enhances CD79A phosphorylation, possibly recruiting kinases or protective proteins. CD79B Protein, Mouse (HEK293, Fc) is the recombinant mouse-derived CD79B protein, expressed by HEK293 , with C-hFc labeled tag. The total length of CD79B Protein, Mouse (HEK293, Fc) is 133 a.a., with molecular weight of 50-65 kDa.

CD79B 蛋白与 CD79A 结合对于启动 B 细胞抗原受体复合物 (BCR) 触发的信号转导级联至关重要。这种级联导致复合物的内化，将其运输到晚期内体，并促进抗原呈递。CD79B 可能通过招募磷酸化 CD79A 的激酶或招募与 CD79A 结合的蛋白质来保护其免于去磷酸化，从而增强 CD79A 的磷酸化。CD79B 与 CD79A 形成二硫键连接的异二聚体，是 B 细胞抗原受体复合物的重要组成部分。在此复合物中，CD79B 和 CD79A 的 α/β 链异二聚体与由两条重链和两条轻链组成的抗原特异性膜结合表面免疫球蛋白非共价结合。CD79B 还与 LYN 相互作用。

Mouse

HEK293

C-hFc

P15530 (V26-D158)

15985  [NCBI]

VPAMTSSDLPLNFQGSPCSQIWQHPRFAAKKRSSMVKFHCYTNHSGALTWFRKRGSQQPQELVSEEGRIVQTQNGSVYTLTIQNIQYEDNGIYFCKQKCDSANHNVTDSCGTELLVLGFSTLDQLKRRNTLKD

50-65 kDa

Greater than 95% as determined by reducing SDS-PAGE.

无菌粉末.

Lyophilized from a 0.2 μm filtered solution of PBS, pH 7.4.

<1 EU/μg, determined by LAL method.

It is not recommended to reconstitute to a concentration less than 100 μg/mL in ddH₂O. For long term storage it is recommended to add a carrier protein (0.1% BSA, 5% HSA, 10% FBS or 5% Trehalose).

Stored at -20°C for 2 years. After reconstitution, it is stable at 4°C for 1 week or -20°C for longer (with carrier protein). It is recommended to freeze aliquots at -20°C or -80°C for extended storage.

Room temperature in continental US; may vary elsewhere.