1. 重组蛋白
  2. Receptor Proteins
  3. Cell Adhesion Molecules (CAMs)
  4. Immunoglobulin-like Cell Adhesion Molecules
  5. Biliary Glycoprotein/CD66a
  6. CEACAM1 蛋白, Mouse (HEK293, Fc)

CEACAM1 蛋白, Mouse (HEK293, Fc)

目录号: HY-P75360
产品使用指南

CEACAM1 蛋白是一种细胞粘附分子,可介导不依赖于钙的同源细胞粘附。CEACAM1 负向调节中性粒细胞和血小板功能,下调 CSF3R-STAT3 通路,并调节胰岛素清除和脂肪生成。CEACAM1 蛋白, Mouse (HEK293, Fc) 是重组的 CEACAM1 蛋白,由 HEK293 表达,带有 C-hFc 标签。

MCE 的所有产品仅用作科学研究或药证申报,我们不为任何个人用途提供产品和服务

SPR 检测服务   重组蛋白定制服务

1.  客户无需承担相应的运输费用。

2.  同一机构(单位)同一产品试用装仅限申领一次,同一机构(单位)一年内

     可免费申领三个不同产品的试用装。

3.  试用装只面向终端客户

规格 是否有货
50 μg   询价  
100 μg   询价  

* Please select Quantity before adding items.

  • 生物活性

  • 技术参数

  • 产品性质

  • 产品资料

描述

The CEACAM1 protein is a cell adhesion molecule that mediates calcium-independent homologous cell adhesion. CEACAM1 negatively regulates neutrophil and platelet function, downregulates the CSF3R-STAT3 pathway, and modulates insulin clearance and lipogenesis. CEACAM1 Protein, Mouse (HEK293, Fc) is the recombinant mouse-derived CEACAM1 protein, expressed by HEK293 , with C-hFc labeled tag.

研究背景

CEACAM1 蛋白作为细胞粘附分子,以不依赖于钙的方式介导同质细胞粘附。它作为免疫反应和胰岛素作用中的共抑制受体发挥多方面的作用,同时也在血管生成过程中充当激活剂。通过磷酸化和 PTPN6 依赖性机制,CEACAM1 抑制相关受体的信号转导,抑制 T 细胞的细胞毒性、增殖和细胞因子的产生。此外,它还通过与HAVCR2相互作用来调节自身免疫和抗肿瘤免疫。在 NK 细胞中,它抑制 KLRK1 介导的细胞溶解并负向调节中性粒细胞中 IL1B 的产生。CEACAM1 通过充当 CSF3R 的共抑制受体来下调中性粒细胞的产生,并且还通过促进 INS 清除和控制肝脏中的脂肪生成来调节胰岛素作用。此外,它还充当血管生成的激活剂,促进血管重塑和动脉生成。CEACAM1 调节血管通透性,下调 EGF 反应的细胞生长,抑制血小板聚集,负向调节破骨细胞生成,并有助于调节与微生物群控制和抵抗肠道病原体相关的 IgA 产生和分泌。

种属

Mouse

表达系统

HEK293

标签

C-hFc

蛋白编号

Q925P3/NP_001034274.1 (E35-G428)

基因 ID
蛋白结构
N-term
CEACAM1 (E35-G428)
Accession # Q925P3/NP_001034274.1
hFc
C-term
同用名
Carcinoembryonic antigen-related cell adhesion molecule 1; BGP-1; CD66a; CEACAM1
分子量

Approximately 70.3 kDa

纯度

Greater than 85% as determined by reducing SDS-PAGE

内毒素含量

<1 EU/μg, determined by LAL method.

文件资料
Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

  • 复溶计算器

  • 重组蛋白稀释计算器

  • 比活力计算器

The reconstitution calculator equation

Volume (to add to vial) = Mass (in vial) ÷ Desired Reconstitution Concentration

Volume (to add to vial) = Mass (in vial) ÷ Desired Reconstitution Concentration
= ÷

The dilution calculator equation

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

This equation is commonly abbreviated as: C1V1 = C2V2

浓度 (start) × 体积 (start) = 浓度 (final) × 体积 (final)
× = ×
C1   V1   C2   V2

The specific activity calculator equation

Specific Activity (Unit/mg) = 106 ÷ Biological Activity (ED50)

Specific Activity (Unit/mg) = 106 ÷ Biological Activity (ED50)
Unit/mg = 106 ÷ ng/mL

您最近查看的产品:

Your information is safe with us. * Required Fields.

   产品名称:

 

* 需求量:

* 客户姓名:

 

* Email:

* 电话:

 

* 公司或机构名称:

   留言给我们:

Bulk Inquiry

Inquiry Information

产品名称:
CEACAM1 Protein, Mouse (HEK293, Fc)
目录号:
HY-P75360
需求量: