CHD1L 蛋白, Human (His-SUMO)

CHD1L protein is the ATP-binding subunit of the mitochondrial potassium channel and cooperates with CCDC51/MITOK to form a complex to promote ATP-dependent potassium current across the inner membrane (mitoK(ATP) channel). ABCB8 is essential for mitochondrial iron transport, affects cardiac function, and regulates the maturation of cytosolic iron-sulfur-containing enzymes. CHD1L Protein, Human (His-SUMO) is the recombinant human-derived CHD1L protein, expressed by E. coli , with N-His, N-SUMO labeled tag. The total length of CHD1L Protein, Human (His-SUMO) is 194 a.a., with molecular weight of ~37.3 kDa.

ABCB8 是位于线粒体内膜的线粒体钾通道的 ATP 结合亚基。它与 CCDC51/MITOK 合作，形成位于线粒体内的蛋白质复合物，促进 ATP 依赖性钾电流穿过内膜，称为 mitoK(ATP) 通道。此外，ABCB8 在线粒体铁转运中发挥着至关重要的作用，对于维持正常心脏功能至关重要，可能影响线粒体铁输出并调节胞质含铁硫簇酶的成熟。值得注意的是，通道活性由 ATP 通过 ABCB8/MITOSUR 亚基调节。

Human

E. coli

N-His;N-SUMO

Q86WJ1 (S704-P897)

9557  [NCBI]

SAELDYQDPDATSLKYVSGDVTHPQAGAEDALIVHCVDDSGHWGRGGLFTALEKRSAEPRKIYELAGKMKDLSLGGVLLFPVDDKESRNKGQDLLALIVAQHRDRSNVLSGIKMAALEEGLKKIFLAAKKKKASVHLPRIGHATKGFNWYGTERLIRKHLAARGIPTYIYYFPRSKSAVLHAQSSSSSSRQLVP

Approximately 37.3 kDa

Greater than 90% as determined by reducing SDS-PAGE.

<1 EU/μg, determined by LAL method.