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  3. CLIC4/Chloride intracellular channel 4 蛋白, Human (His)

CLIC4/Chloride intracellular channel 4 蛋白, Human (His)

目录号: HY-P70120
产品使用指南

CLIC4/氯离子 细胞内通道 4 蛋白插入膜中,形成 pH 依赖性、选择性差的离子通道,用于运输氯离子。它增强 HRH3 的细胞表面表达,并在血管生成、有丝分裂、胞质分裂、内皮细胞增殖和形态发生过程中维持膜极性。CLIC4/Chloride intracellular channel 4 蛋白, Human (His) 是重组的 CLIC4/氯化物细胞内通道 4 蛋白,由 E. coli 表达,带有 N-6*His 标签。

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描述

CLIC4/Chloride The intracellular channel 4 protein inserts into the membrane to form a pH-dependent, poorly selective ion channel that transports chloride ions.It enhances cell surface expression of HRH3 and maintains membrane polarity during angiogenesis, mitosis, cytokinesis, endothelial cell proliferation, and morphogenesis.CLIC4/Chloride intracellular channel 4 Protein, Human (His) is the recombinant human-derived CLIC4/Chloride intracellular channel 4 protein, expressed by E.coli , with N-6*His labeled tag.

研究背景

CLIC4,被称为氯离子细胞内通道4,能够插入细胞膜,形成选择性差的离子通道,可能促进氯离子转运。其通道活性依赖于 pH 值,并且其膜插入似乎受氧化还原调节,特别是在氧化条件下发生。除了离子转运之外,CLIC4 还发挥多种作用,包括促进 HRH3 的细胞表面表达并参与各种细胞功能,例如血管生成、有丝分裂和胞质分裂期间顶基底外侧膜极性的维持以及内皮细胞增殖和形态发生的调节。它是涉及肌动蛋白、埃兹蛋白、α-肌动蛋白、凝溶胶蛋白、IQGAP1 和 CLIC5A 等细胞骨架蛋白的多聚体复合物的一部分。CLIC4 在包含肌动蛋白、微管蛋白和 14-3-3 亚型的复合物中直接与脑动力 I 相互作用,并且还与 HRH3 和 AKAP9 相互作用。

种属

Human

表达系统

E. coli

标签

N-6*His

蛋白编号

Q9Y696 (M1-K253)

基因 ID
蛋白结构
N-term
6*His
CLIC4 (M1-K253)
Accession # Q9Y696
C-term
同用名
rHuChloride intracellular channel protein 4/CLIC4, His; Chloride Intracellular Channel Protein 4; Intracellular Chloride Ion Channel Protein p64H1; CLIC4
氨基酸序列

MALSMPLNGLKEEDKEPLIELFVKAGSDGESIGNCPFSQRLFMILWLKGVVFSVTTVDLKRKPADLQNLAPGTHPPFITFNSEVKTDVNKIEEFLEEVLCPPKYLKLSPKHPESNTAGMDIFAKFSAYIKNSRPEANEALERGLLKTLQKLDEYLNSPLPDEIDENSMEDIKFSTRKFLDGNEMTLADCNLLPKLHIVKVVAKKYRNFDIPKEMTGIWRYLTNAYSRDEFTNTCPSDKEVEIAYSDVAKRLTK

分子量

Approximately 32.0 kDa

纯度

Greater than 95% as determined by reducing SDS-PAGE

内毒素含量

<1 EU/μg, determined by LAL method.

文件资料

CLIC4/Chloride intracellular channel 4 Protein, Human (His) 相关分类

Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

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The reconstitution calculator equation

Volume (to add to vial) = Mass (in vial) ÷ Desired Reconstitution Concentration

Volume (to add to vial) = Mass (in vial) ÷ Desired Reconstitution Concentration
= ÷

The dilution calculator equation

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

This equation is commonly abbreviated as: C1V1 = C2V2

浓度 (start) × 体积 (start) = 浓度 (final) × 体积 (final)
× = ×
C1   V1   C2   V2

The specific activity calculator equation

Specific Activity (Unit/mg) = 106 ÷ Biological Activity (ED50)

Specific Activity (Unit/mg) = 106 ÷ Biological Activity (ED50)
Unit/mg = 106 ÷ ng/mL

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产品名称:
CLIC4/Chloride intracellular channel 4 Protein, Human (His)
目录号:
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