Chordin-like 1/CHRDL1 蛋白, Human (N-His)

The CHRDL1 protein acts as a BMP4 antagonist, blocking its receptor interaction and redirecting neural stem cells from gliogenesis to neurogenesis. The role of CHRDL1 in preventing glial cell fate adoption supports neuronal differentiation in the brain. Chordin-like 1/CHRDL1 Protein, Human (N-His) is the recombinant human-derived Chordin-like 1/CHRDL1 protein, expressed by E. coli , with N-His labeled tag.

类脊索蛋白 1 (CHRDL1) 蛋白通过与 BMP4 结合而充当 BMP4 的拮抗剂，从而阻止其与受体的相互作用。这种相互作用导致神经干细胞命运的转变，引导它们从胶质细胞发生转向神经发生。CHRDL1 参与阻止神经胶质命运的采用，有助于大脑中神经干细胞的神经元分化。除了在神经发育中的作用之外，CHRDL1 可能在背腹轴形成和胚胎骨发育中发挥重要作用（通过相似性）。此外，CHRDL1 还通过调节内皮细胞中 BMP4 的作用来调节视网膜血管生成。它对眼前节发育的参与强调了它在各种发育过程中的多方面作用。

Immobilized Human CHRDL1, His Tag at 1μg/ml (100μl/Well) on the plate. Dose response curve for Anti-CHRDL1 Antibody, hFc Tag with the EC₅₀ of 9.4 ng/ml determined by ELISA.

Human

E. coli

N-His

Q9BU40-1 (E28-C456)

91851

Approximately 50 kDa

Greater than 95% as determined by Tris-Bis PAGE.

无菌粉末.

Lyophilized from a 0.22 μm filtered solution of 4 mM HCl, pH 4.0. Normally 8 % trehalose is added as protectant before lyophilization.

<1 EU/μg, determined by LAL method.

It is not recommended to reconstitute to a concentration less than 100 μg/mL in ddH₂O.

Stored at -20°C for 2 years. After reconstitution, it is stable at 4°C for 1 week or -20°C for longer (with carrier protein). It is recommended to freeze aliquots at -20°C or -80°C for extended storage.

Room temperature in continental US; may vary elsewhere.