CIRBP 蛋白, Human (His)

CIRBP is a cold-induced mRNA-binding protein that plays a key role in cellular responses to genotoxic stress, exerting a protective effect by stabilizing transcripts of genes critical for cell survival. As a translation activator, CIRBP appears to be critical for cold-induced inhibition of cell proliferation. CIRBP Protein, Human (His) is the recombinant human-derived CIRBP protein, expressed by E. coli , with N-His labeled tag. The total length of CIRBP Protein, Human (His) is 172 a.a., with molecular weight of ~23 KDa.

冷诱导 RNA 结合蛋白 (CIRBP) 在细胞对基因毒性应激的反应中发挥着重要作用，通过稳定与细胞存活相关的基因转录发挥保护作用。作为翻译激活剂，CIRBP 参与冷诱导的细胞增殖抑制，并与 RPA2 和 TXN 等应激反应转录本的 3'-非翻译区 (3'-UTR) 特异性结合。它充当翻译抑制子，在过度表达时促进应激颗粒 (SG) 的组装。此外，CIRBP 与 EIF4G1 相互作用并与核糖体结合，强调其在细胞应激反应和 RNA 加工中的多方面参与（参考：提供的信息）。

Human

E. coli

N-His

Q14011-1 (M1-E172)

1153  [NCBI]

Approximately 23 kDa.

Greater than 90% as determined by reducing SDS-PAGE

溶液

Supplied as a 0.22 μm filtered solution of 20 mM Tris, 500 mM NaCl, 0.25M Imi, 20% glycerol.

/

N/A.

Stored at -80°C for 1 year. It is stable at -20°C for 3 months after opening. It is recommended to freeze aliquots at -80°C for extended storage. Avoid repeated freeze-thaw cycles.

Shipping with dry ice.