CLEC-1/CLEC1A 蛋白, Mouse (HEK293, hFc)

CLEC-1/CLEC1A proteins belong to the CTL/CTLD superfamily and are known for their diverse functions in cell adhesion, signaling, glycoprotein turnover, inflammation, and immune responses. It is involved in potentially regulating dendritic cell function. CLEC-1/CLEC1A Protein, Mouse (HEK293, hFc) is the recombinant mouse-derived CLEC-1/CLEC1A protein, expressed by HEK293 , with N-hFc labeled tag.

型凝集素样结构域蛋白 1 (CLEC1A) 是 C 型凝集素/C 型凝集素样结构域 (CTL/CTLD) 超家族的成员，以其多种功能而闻名，包括细胞粘附、细胞-细胞信号传导、糖蛋白周转以及在炎症和免疫反应中的作用。该蛋白参与树突状细胞功能的潜在调节。CLEC1A 位于自然杀伤基因复合体区域的染色体 12p13 上，与 CTL/CTLD 超家族的其他成员密切相关。选择性剪接产生多种转录变体，从而导致该基因的功能多样性。CLEC1A 在胎盘 (RPKM 18.1)、肺 (RPKM 3.8) 和 10 个其他组织中观察到偏向表达，强调了其在各种生理环境中的潜在作用。

Measured by its ability to bind fluorescein-conjugated E.coli Bioparticles. The ED₅₀ for this effect is 2.703 μg/mL, corresponding to a specific activity is 3.70×10² units/mg.

Mouse

HEK293

N-hFc

Q8BWY2 (Q73-Q269)

243653  [NCBI]

QFYQLSNIQQDSITEKDEKLGNMSRQLQSLQAQNRKLIETLQQVAVKLCRELYNKSGGHRCSPCPEKWKWYGDKCYQFYKESKNWQSCEYFCLADNATMLKISTQEELDFAMPQSYSEFFYSYWTGLSRNGSGKAWLWTDGTPYSFELFEIIIDPTNLRNRDCMTIFNGKAYSKDCKELRRCACERIAGRVVPGELQ

Approximately 58-80 kDa due to the glycosylation.

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  Greater than 95% as determined by reducing SDS-PAGE.

无菌粉末

Lyophilized from a 0.2 μm filtered solution of PBS, pH 7.4.

<1 EU/μg, determined by LAL method.

It is not recommended to reconstitute to a concentration less than 100 μg/mL in ddH₂O. For long term storage it is recommended to add a carrier protein (0.1% BSA, 5% HSA, 10% FBS or 5% Trehalose).

Stored at -20°C for 2 years. After reconstitution, it is stable at 4°C for 1 week or -20°C for longer (with carrier protein). It is recommended to freeze aliquots at -20°C or -80°C for extended storage.

Room temperature in continental US; may vary elsewhere.