COL4A3 蛋白, Human (His)

The COL4A3 protein is an important type IV collagen component that, together with laminin, proteoglycans, and nestin/nesidin, plays a role in forming the "chicken wire" network structure in the glomerular basement membrane (GBM). Key role. Its cleavage product tumstatin is derived from the NC1 domain of collagen α 3(IV) and has dual anti-angiogenic and anti-tumor cell activities. COL4A3 Protein, Human (His) is the recombinant human-derived COL4A3 protein, expressed by E. coli , with N-6*His labeled tag. The total length of COL4A3 Protein, Human (His) is 242 a.a., with molecular weight of ~30.6 kDa.

COL4A3 蛋白是 IV 型胶原蛋白的重要组成部分，是肾小球基底膜 (GBM) 的主要结构元件，与层粘连蛋白、蛋白聚糖和巢蛋白/巢蛋白一起参与“鸡丝”网络的形成。值得注意的是，tumstatin 是一种源自胶原蛋白 α 3(IV) NC1 结构域的裂解片段，具有双重抗血管生成和抗肿瘤细胞活性。这些抗肿瘤特性的调节似乎涉及 ITGB3 介导的不依赖于 RGD 的机制，这凸显了 COL4A3 在影响血管生成和肿瘤细胞行为中的复杂作用。

Human

E. coli

N-6*His

Q01955 (G1427-K1668)

1285  [NCBI]

GLKGKRGDSGSPATWTTRGFVFTRHSQTTAIPSCPEGTVPLYSGFSFLFVQGNQRAHGQDLGTLGSCLQRFTTMPFLFCNVNDVCNFASRNDYSYWLSTPALMPMNMAPITGRALEPYISRCTVCEGPAIAIAVHSQTTDIPPCPHGWISLWKGFSFIMFTSAGSEGTGQALASPGSCLEEFRASPFLECHGRGTCNYYSNSYSFWLASLNPERMFRKPIPSTVKAGELEKIISRCQVCMKK

Approximately 30.6 kDa

Greater than 90% as determined by reducing SDS-PAGE.

无菌粉末.

Lyophilized from a 0.2 μm solution of PBS, 6% Trehalose, pH 7.4.

<1 EU/μg, determined by LAL method.

It is not recommended to reconstitute to a concentration less than 100 μg/mL in ddH₂O.

Stored at -20°C for 2 years. After reconstitution, it is stable at 4°C for 1 week or -20°C for longer (with carrier protein). It is recommended to freeze aliquots at -20°C or -80°C for extended storage.

Room temperature in continental US;may vary elsewhere.