Collagen alpha-1(III) chain/COL3A 蛋白, Mouse (HEK293, His)

COL3A protein, also known as collagen α-1(III) chain, is an important component of type III collagen and is widely distributed along with type I collagen in most soft connective tissues. In addition to its structural role, COL3A is also involved in the regulation of cortical development. Collagen alpha-1 (III) chain/COL3A Protein, Mouse (HEK293, His) is the recombinant mouse-derived Collagen alpha-1(III) chain/COL3A protein, expressed by HEK293 , with C-6*His labeled tag. The total length of Collagen alpha-1 (III) chain/COL3A Protein, Mouse (HEK293, His) is 1065 a.a., with molecular weight of ~130.0 kDa.

胶原蛋白 alpha-1(III) 链由 COL3A 基因编码，是 III 型胶原蛋白的重要组成部分，与 I 型胶原蛋白一起广泛存在于各种软结缔组织中。这种蛋白质在皮质发育的复杂调节中发挥着至关重要的作用。特别值得注意的是它在发育中的大脑中作为 ADGRG1 的主要配体的作用。胶原蛋白 α-1(III) 链与 ADGRG1 的结合具有深远的影响，包括抑制神经元迁移和激活 RhoA 通路。这种激活是通过促进 ADGRG1 与 GNA13 以及可能的 GNA12 的偶联来实现的。胶原蛋白α-1(III)链的三聚结构由相同的α1(III)链组成，通过链间二硫键连接，并通过羟基赖氨酸交联进一步稳定。这种复杂的相互作用凸显了胶原蛋白 α-1(III) 链在发育过程中的多方面参与，特别是在神经元调节的背景下。（参考：提供的资料）

Mouse

HEK293

C-6*His

P08121 (Q155-G1219)

12825  [NCBI]

QFDSYDVKSGVGGMGGYPGPAGPPGPPGPPGSSGHPGSPGSPGYQGPPGEPGQAGPAGPPGPPGALGPAGPAGKDGESGRPGRPGERGLPGPPGIKGPAGMPGFPGMKGHRGFDGRNGEKGETGAPGLKGENGLPGDNGAPGPMGPRGAPGERGRPGLPGAAGARGNDGARGSDGQPGPPGPPGTAGFPGSPGAKGEVGPAGSPGSNGSPGQRGEPGPQGHAGAQGPPGPPGNNGSPGGKGEMGPAGIPGAPGLIGARGPPGPAGTNGIPGTRGPSGEPGKNGAKGEPGARGERGEAGSPGIPGPKGEDGKDGSPGEPGANGLPGAAGERGPSGFRGPAGPNGIPGEKGPPGERGGPGPAGPRGVAGEPGRDGTPGGPGIRGMPGSPGGPGNDGKPGPPGSQGESGRPGPPGPSGPRGQPGVMGFPGPKGNDGAPGKNGERGGPGGPGLPGPAGKNGETGPQGPPGPTGPAGDKGDSGPPGPQGLQGIPGTGGPPGENGKPGEPGPKGEVGAPGAPGGKGDSGAPGERGPPGTAGIPGARGGAGPPGPEGGKGPAGPPGPPGASGSPGLQGMPGERGGPGSPGPKGEKGEPGGAGADGVPGKDGPRGPAGPIGPPGPAGQPGDKGEGGSPGLPGIAGPRGGPGERGEHGPPGPAGFPGAPGQNGEPGAKGERGAPGEKGEGGPPGPAGPTGSSGPAGPPGPQGVKGERGSPGGPGTAGFPGGRGLPGPPGNNGNPGPPGPSGAPGKDGPPGPAGNSGSPGNPGIAGPKGDAGQPGEKGPPGAQGPPGSPGPLGIAGLTGARGLAGPPGMPGPRGSPGPQGIKGESGKPGASGHNGERGPPGPQGLPGQPGTAGEPGRDGNPGSDGQPGRDGSPGGKGDRGENGSPGAPGAPGHPGPPGPVGPSGKSGDRGETGPAGPSGAPGPAGARGAPGPQGPRGDKGETGERGSNGIKGHRGFPGNPGPPGSPGAAGHQGAIGSPGPAGPRGPVGPHGPPGKDGTSGHPGPIGPPGPRGNRGERGSEGSPGHPGQPGPPGPPGAPGPCCGGGAAAIAGVGGEKSGGFSPYYG

Approximately 130.0 kDa

Greater than 95% as determined by reducing SDS-PAGE

溶液.

Supplied as a 0.2 μm filtered solution of 20 mM HAc-NaAc, 150 mM NaCl, pH 4.5.

<1 EU/μg, determined by LAL method.

Stored at -80°C for 1 year. It is stable at -20°C for 3 months after opening. It is recommended to freeze aliquots at -80°C for extended storage. Avoid repeated freeze-thaw cycles.

Shipping with dry ice.

• [1]. Guidong Yao, et al. Lnc-GULP1-2:1 affects granulosa cell proliferation by regulating COL3A1 expression and localization. J Ovarian Res. 2021 Jan 20;14(1):16.  [Content Brief]

  [2]. Yihong Wang, et al. Collagen type III α1 as a useful diagnostic immunohistochemical marker for fibroepithelial lesions of the breast. Hum Pathol. 2016 Nov;57:176-181.  [Content Brief]