Collectrin/TMEM27 蛋白, Human (HEK293, Fc)

Collectrin, also known as TMEM27, plays a key role in amino acid transport by binding to SLC6A18 and SLC6A19 and regulating their surface trafficking and amino acid transporter activity. Suggested to facilitate the trafficking of SLC3A1 and SLC7A9 to the renal cortical cell membrane. Collectrin/TMEM27 Protein, Human (HEK293, Fc) is the recombinant human-derived Collectrin/TMEM27 protein, expressed by HEK293 , with C-hFc labeled tag. The total length of Collectrin/TMEM27 Protein, Human (HEK293, Fc) is 127 a.a., with molecular weight of 53-57 kDa.

Collectrin 蛋白也称为 TMEM27，通过作为氨基酸转运蛋白 SLC6A18 和 SLC6A19 的结合伴侣，在氨基酸转运中发挥关键作用，从而调节它们在细胞表面的运输并影响其氨基酸转运蛋白活性。它被认为有助于氨基酸转运蛋白 SLC3A1 和 SLC7A9 运输至肾皮质细胞膜。此外，Collectrin 还充当 SNARE 复合体功能的调节剂，并充当 β 细胞复制的刺激剂。从结构上看，Collectrin 既以单体形式存在，也以同型二聚体形式存在，二聚化可防止 BACE2 裂解 CLTRN。在分子相互作用方面，Collectrin与SLC6A18和SLC6A19相互作用，复杂地调节它们的膜运输和氨基酸转运蛋白活性，同时还与SNAPIN形成相互作用。这些发现强调了 Collectrin 在氨基酸转运和细胞过程中的多方面参与，强调了它在维持适当的细胞功能中的关键作用。

Human

HEK293

C-hFc

Q9HBJ8 (E15-P141)

57393  [NCBI]

ELCQPGAENAFKVRLSIRTALGDKAYAWDTNEEYLFKAMVAFSMRKVPNREATEISHVLLCNVTQRVSFWFVVTDPSKNHTLPAVEVQSAIRMNKNRINNAFFLNDQTLEFLKIPSTLAPPMDPSVP

53-57 kDa

Greater than 95% as determined by reducing SDS-PAGE

无菌粉末

Lyophilized from a 0.2 μm filtered solution of PBS, pH 7.4.

<1 EU/μg, determined by LAL method.

It is not recommended to reconstitute to a concentration less than 100 μg/mL in ddH₂O. For long term storage it is recommended to add a carrier protein (0.1% BSA, 5% HSA, 10% FBS or 5% Trehalose).

Stored at -20°C for 2 years. After reconstitution, it is stable at 4°C for 1 week or -20°C for longer (with carrier protein). It is recommended to freeze aliquots at -20°C or -80°C for extended storage.

Room temperature in continental US; may vary elsewhere.