2. 重组蛋白
  3. Complement System Biotinylated Proteins
  4. Complement Component 5
  5. Complement Component 5a
  6. Complement C5/C5a 蛋白, Mouse (Biotinylated)

Complement C5/C5a 蛋白, Mouse (Biotinylated)

目录号: HY-P77540
产品使用指南

补体 C5/C5a 蛋白激活晚期补体成分，形成膜攻击复合物 C5-C9。C5b 结合 C6，启动裂解复合物组装。C5a 由 C5 降解产生，作为过敏毒素，诱发局部炎症。C5a 刺激细胞内钙释放、平滑肌收缩、血管通透性、组胺释放，并充当趋化因子，引导白细胞迁移。Complement C5/C5a 蛋白, Mouse (Biotinylated) 是重组的 补充 C5/C5a 蛋白，由 E. coli 表达，不带标签。Complement C5/C5a 蛋白, Mouse (Biotinylated) 全长 77 个氨基酸，分子量约为 ~9 KDa。

MCE 的所有产品仅用作科学研究或药证申报，我们不为任何个人用途提供产品和服务

SPR 检测服务   重组蛋白定制服务

1.  客户无需承担相应的运输费用。

2.  同一机构（单位）同一产品试用装仅限申领一次，同一机构（单位）一年内

     可免费申领三个不同产品的试用装。

3.  试用装只面向终端客户。

规格 是否有货
50 μg   询价  
100 μg   询价  

* Please select Quantity before adding items.

Top Publications Citing Use of Products

  • 生物活性

  • 技术参数

  • 产品性质

  • 产品资料

描述

Complement C5/C5a Protein activates late complement components to form the membrane attack complex, C5-C9. C5b binds C6, initiating lytic complex assembly. C5a, produced by C5 degradation, acts as an anaphylatoxin, inducing local inflammation. C5a stimulates intracellular calcium release, smooth muscle contraction, vascular permeability, histamine release, and acts as a chemokine, guiding leukocyte migration. Complement C5/C5a Protein, Mouse (Biotinylated) is the recombinant mouse-derived Complement C5/C5a protein, expressed by E. coli, with tag free. The total length of Complement C5/C5a Protein, Mouse (Biotinylated) is 77 a.a., with molecular weight of ~9 KDa.
研究背景

补体 C5/C5a 蛋白被 C5 转化酶激活时，会触发后期补体成分自发组装成膜攻击复合物 C5-C9。C5b 形成 C6 的瞬时结合位点，形成裂解复合物组装的基础。同时，通过补体 C5 的蛋白水解降解产生的 C5a，充当介导局部炎症过程的过敏毒素。它与受体 C5AR1 的结合诱导各种反应，例如细胞内钙释放、平滑肌收缩、血管通透性增加以及肥大细胞和嗜碱性白细胞释放组胺。此外，C5a 作为一种有效的趋化因子，刺激多形核白细胞的运动并引导它们向发炎区域迁移。
种属

Mouse
表达系统

E. coli
标签

Tag Free
蛋白编号

P06684 (N679-R755)
基因 ID
蛋白结构
N-term
C5a (N679-R755)
Accession # P06684
C-term
同用名
Complement C5; Hemolytic Complement; C5a
分子量

Approximately 9 kDa.
纯度

Greater than 95% as determined by reducing SDS-PAGE.
内毒素含量

<1 EU/μg, determined by LAL method.
文件资料
产品使用指南 (1213 KB)

Complement C5/C5a Protein, Mouse (Biotinylated) 相关分类

Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

  • 复溶计算器

  • 重组蛋白稀释计算器

  • 比活力计算器

The reconstitution calculator equation

Volume (to add to vial) = Mass (in vial) ÷ Desired Reconstitution Concentration

Volume (to add to vial) = Mass (in vial) ÷ Desired Reconstitution Concentration
= ÷

The dilution calculator equation

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

This equation is commonly abbreviated as: C1V1 = C2V2

浓度 (start) × 体积 (start) = 浓度 (final) × 体积 (final)
× = ×
C1   V1   C2   V2

The specific activity calculator equation

Specific Activity (Unit/mg) = 106 ÷ Biological Activity (ED50)

Specific Activity (Unit/mg) = 106 ÷ Biological Activity (ED50)
Unit/mg = 106 ÷ ng/mL

您最近查看的产品:

Your information is safe with us. * Required Fields.

   产品名称：

  

* 需求量：

* 客户姓名：

 

* Email：

* 电话：

 

* 公司或机构名称：

   留言给我们：

Bulk Inquiry

Inquiry Information

产品名称：
Complement C5/C5a Protein, Mouse (Biotinylated)
目录号：
HY-P77540
需求量：

Request for HNMR Report

Please fill out this form to request the QC report. We will send it to your Email address shortly.

Your information is safe with us. * Required Fields.

   产品名称：

  

* Lot #：

* 客户姓名：

 

* Email：

* 电话：

 

* 公司或机构名称：

   留言给我们：

Request for HNMR Report

We have received your request and will respond to you as soon as possible.

嗨！很高兴为您提供帮助！

尊敬的 MCE 客户您好，
请您选择所在区域，我们将转接对应客服为您服务！

热门区域

A

B

C

F

G

H

J

L

N

Q

S

T

X

Y

Z

热 A B C F G H J L N Q S T X Y Z