Complement Factor D/Adipsin 蛋白, Human (HEK293, His)

Complement factor D, also known as Adipsin, plays a crucial role in the alternative pathway of the complement system and when complexed with factor C3b, it cleaves factor B. This cleavage activates the C3bbb complex, converting it to the C3 convertase of the alternative pathway. Complement Factor D/Adipsin Protein, Human (HEK293, His) is the recombinant human-derived Complement Factor D/Adipsin protein, expressed by HEK293 , with C-10*His labeled tag. The total length of Complement Factor D/Adipsin Protein, Human (HEK293, His) is 228 a.a., with molecular weight of ~28.0 kDa.

补体因子 D，也称为 Adipsin，是补体系统替代途径中的重要组成部分。因子 D 的功能与经典途径中的 C1 类似，在 C3 转化酶的激活中发挥着关键作用。具体而言，当因子 B 与因子 C3b 复合时，因子 D 会裂解因子 B。这种酶活性导致活性 C3bbb 复合物的生成，该复合物充当替代途径中的 C3 转化酶。D 因子与 C1s 的同源功能强调了其在启动补体级联中的重要性，强调了其在免疫反应中的作用。

Human

HEK293

C-10*His

P00746 (I26-A253)

1675  [NCBI]

ILGGREAEAHARPYMASVQLNGAHLCGGVLVAEQWVLSAAHCLEDAADGKVQVLLGAHSLSQPEPSKRLYDVLRAVPHPDSQPDTIDHDLLLLQLSEKATLGPAVRPLPWQRVDRDVAPGTLCDVAGWGIVNHAGRRPDSLQHVLLPVLDRATCNRRTHHDGAITERLMCAESNRRDSCKGDSGGPLVCGGVLEGVVTSGSRVCGNRKKPGIYTRVASYAAWIDSVLA

Approximately 28.0 kDa

Greater than 95% as determined by reducing SDS-PAGE

无菌粉末.

Lyophilized from a 0.2 μm filtered solution of 20 mM Tris-HCl, 150 mM NaCl, pH 7.5.

<1 EU/μg, determined by LAL method.

It is not recommended to reconstitute to a concentration less than 100 μg/mL in ddH₂O. For long term storage it is recommended to add a carrier protein (0.1% BSA, 5% HSA, 10% FBS or 5% Trehalose).

Stored at -20°C for 2 years. After reconstitution, it is stable at 4°C for 1 week or -20°C for longer (with carrier protein). It is recommended to freeze aliquots at -20°C or -80°C for extended storage.

Room temperature in continental US; may vary elsewhere.