Contactin-1/CNTN1 蛋白, Human (HEK293, His)

Contactin-1/CNTN1 proteins mediate cell surface interactions in the developing nervous system. Contactin-1/CNTN1 Protein, Human (HEK293, His) is the recombinant human-derived Contactin-1/CNTN1, expressed by HEK293 , with C-His labeled tag. The total length of Contactin-1/CNTN1 Protein, Human (HEK293, His) is 973 a.a.,

Contactin-1 (CNTN1) 蛋白是神经系统发育的关键蛋白，可促进关键的细胞表面相互作用。它在有髓周围神经内结节旁轴-神经胶质连接的形成中发挥重要作用，并通过与 CNTNAP1 关联而有助于轴突和有髓神经胶质细胞之间的信号传导。此外，CNTN1 参与少突胶质细胞的生成，充当 NOTCH1 的配体。与 NOTCH1 的结合促进了 NOTCH1 的激活，导致 notch 胞内结构域 (NICD) 的释放及其随后易位到细胞核。值得注意的是，CNTN1 与 TNR 的相互作用会诱导神经元排斥并抑制神经突生长。在其单体形式中，CNTN1 与 CNTNAP1 顺式相互作用，并与 PTPRZ1 的碳酸酐酶样结构域结合。此外，CNTN1 与 NRCAM 和 PTPRB 形成复合物，并与 TASOR 相互作用。这些多方面的相互作用强调了 Contactin-1 在协调神经系统发育过程中关键过程中的多种功能。

Human

HEK293

C-His

Q12860 (E21-S993)

1272  [NCBI]

Approximately 125 kDa

Greater than 95% as determined by reducing SDS-PAGE.

无菌粉末.

Lyophilized from a 0.2 μm filtered solution of PBS, pH 7.4. Normally 5 % - 8 % trehalose, mannitol and 0.01% Tween 80 are added as protectants before lyophilization.

<1 EU/μg, determined by LAL method.

It is not recommended to reconstitute to a concentration less than 100 μg/mL in ddH₂O.

Stored at -20°C for 2 years. After reconstitution, it is stable at 4°C for 1 week or -20°C for longer (with carrier protein). It is recommended to freeze aliquots at -20°C or -80°C for extended storage.

Room temperature in continental US; may vary elsewhere.