Contactin-3/CNTN3 蛋白, Human (N708D, HEK293, His)

Contactin-3/CNTN3 protein, a member of the contactin family, facilitates cell surface interactions crucial for nervous system development. It exhibits neurite outgrowth-promoting activity, contributing to the intricate processes involved in the formation and maturation of neural circuits. Additionally, Contactin-3/CNTN3 interacts with PTPRG, indicating its involvement in signaling pathways that govern neural cell communication and connectivity. Contactin-3/CNTN3 Protein, Human (N708D, HEK293, His) is the recombinant human-derived Contactin-3/CNTN3 protein, expressed by HEK293 , with C-His labeled tag.

Contactin-3 (CNTN3) 是一种蛋白质，在神经系统发育过程中介导细胞表面相互作用中发挥着至关重要的作用。在功能上，它表现出促进神经突生长的活性，表明它参与促进神经元过程的延伸（通过相似性）。此外，CNTN3 与 PTPRG 相互作用，表明在神经发育过程中调节信号通路或细胞粘附方面具有潜在作用。Contactin-3 及其相互作用伙伴之间复杂的相互作用强调了它在神经系统发育的复杂过程中的重要性，其中细胞表面相互作用和神经突生长对于功能性神经回路的建立至关重要。

Measured by its binding ability in a functional ELISA. When Recombinant Huamn CNTN3 is present at 2 μg/mL, can bind Recombinant Human Amyloid Precursor. The ED₅₀ for this effect is 0.093 μg/mL.

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  Measured by its binding ability in a functional ELISA. When Recombinant Huamn CNTN3 is present at 2 μg/mL, can bind Recombinant Human Amyloid Precursor. The ED₅₀ for this effect is 0.093 μg/mL.

Human

HEK293

C-10*His

Q9P232/NP_065923.1 (E20-S1002, N708D)

5067  [NCBI]

ELLLQGPVFIKEPSNSIFPVGSEDKKITLHCEARGNPSPHYRWQLNGSDIDMSMEHRYKLNGGNLVVINPNRNWDTGTYQCFATNSLGTIVSREAKLQFAYLENFKTKMRSTVSVREGQGVVLLCGPPPHSGELSYAWIFNEYPSFVEEDSRRFVSQETGHLYISKVEPSDVGNYTCVVTSMVTNARVLGSPTPLVLRSDGVMGEYEPKIEVQFPETLPAAKGSTVKLECFALGNPIPQINWRRSDGLPFSSKIKLRKFSGVLEIPNFQQEDAGSYECIAENSRGKNVARGRLTYYAKPHWVQLIKDVEIAVEDSLYWECRASGKPKPSYRWLKNGAALVLEERTQIENGALTISNLSVTDSGMFQCIAENKHGLVYSSAELKVVASAPDFSKNPMKKLVQVQVGSLVSLDCKPRASPRALSSWKKGDVSVQEHERISLLNDGGLKIANVTKADAGTYTCMAENQFGKANGTTHLVVTEPTRITLAPSNMDVSVGESVILPCQVQHDPLLDIIFTWYFNGALADFKKDGSHFEKVGGSSSGDLMIRNIQLKHSGKYVCMVQTGVDSVSSAADLIVRGSPGPPENVKVDEITDTTAQLSWKEGKDNHSPVISYSIQARTPFSVGWQTVTTVPEVIDGKTHTATVVELNPWVEYEFRVVASNKIGGGEPSLPSEKVRTEEAVPEVPPSEVDGGGGSRSELVITWDPVPEELQNGEGFGYVVAFRPLGVTTWIQTVVTSPDTPRYVFRNESIVPYSPYEVKVGVYNNKGEGPFSPVTTVFSAEEEPTVAPSQVSANSLSSSEIEVSWNTIPWKLSNGHLLGYEVRYWNGGGKEESSSKMKVAGNETSARLRGLKSNLAYYTAVRAYNSAGAGPFSATVNVTTKKTPPSQPPGNVVWNATDTKVLLNWEQVKAMENESEVTGYKVFYRTSSQNNVQVLNTNKTSAELVLPIKEDYIIEVKATTDGGDGTSSEQIRIPRITSMDARGS

Approximately 125-135 kDa due to the glycosylation.

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  Greater than 95% as determined by reducing SDS-PAGE.

无菌粉末

Lyophilized from a 0.2 μm filtered solution of PBS, pH 7.4.

<1 EU/μg, determined by LAL method.

It is not recommended to reconstitute to a concentration less than 100 μg/mL in ddH₂O. For long term storage it is recommended to add a carrier protein (0.1% BSA, 5% HSA, 10% FBS or 5% Trehalose).

Stored at -20°C for 2 years. After reconstitution, it is stable at 4°C for 1 week or -20°C for longer (with carrier protein). It is recommended to freeze aliquots at -20°C or -80°C for extended storage.

Room temperature in continental US; may vary elsewhere.