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  3. Cornulin 蛋白, Human (His)

Cornulin 蛋白, Human (His)

目录号: HY-P70116
产品使用指南

Cornulin 蛋白在细胞动力学中至关重要,可促进增殖并促进 G1/S 细胞周期进程,诱导关键调节因子 CCND1。它积极参与 NFKB1 和 PI3K/AKT 通路并对促炎细胞因子做出反应。Cornulin 蛋白, Human (His) 是重组的 Cornulin 蛋白,由 E. coli 表达,带有 N-6*His 标签。Cornulin 蛋白, Human (His) 全长 140 个氨基酸,分子量约为 ~17.0 kDa。

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描述

Cornulin protein is critical in cell dynamics, promoting proliferation and promoting G1/S cell cycle progression, inducing the key regulator CCND1. It actively participates in the NFKB1 and PI3K/AKT pathways and responds to pro-inflammatory cytokines. Cornulin Protein, Human (His) is the recombinant human-derived Cornulin protein, expressed by E. coli , with N-6*His labeled tag. The total length of Cornulin Protein, Human (His) is 140 a.a., with molecular weight of ~17.0 kDa.

研究背景

Cornulin 蛋白通过促进细胞增殖和促进 G1/S 细胞周期进程在细胞动力学中发挥关键作用。它的影响延伸到了 CCND1(一种重要的细胞周期调节因子)的诱导。此外,Cornulin 协调增殖调节以响应促炎细胞因子,积极参与 NFKB1 和 PI3K/AKT 信号通路。Cornulin 作为同二聚体发挥作用,在细胞过程中发挥多方面的作用,有助于细胞周期控制和炎症信号反应的复杂平衡。Cornulin 在这些途径中精心策划的相互作用强调了其在调节细胞增殖中的重要性,并强调了其在生理和病理环境中的潜在影响。需要进一步探索,以全面了解 Cornulin 复杂参与细胞周期调节及其对促炎刺激的反应的具体分子机制。

种属

Human

表达系统

E. coli

标签

N-6*His

蛋白编号

Q9UBG3 (M1-S140)

基因 ID
蛋白结构
N-term
6*His
Cornulin (M1-S140)
Accession # Q9UBG3
C-term
同用名
rHuCornulin, His; Cornulin; 53 kDa Putative Calcium-Binding Protein; 53 kDa Squamous Epithelial-Induced Stress Protein; 58 kDa Heat Shock Protein; Squamous Epithelial Heat Shock Protein 53; Tumor-Related Protein; CRNN; C1orf10; DRC1; PDRC1; SEP53
氨基酸序列

MPQLLQNINGIIEAFRRYARTEGNCTALTRGELKRLLEQEFADVIVKPHDPATVDEVLRLLDEDHTGTVEFKEFLVLVFKVAQACFKTLSESAEGACGSQESGSLHSGASQELGEGQRSGTEVGRAGKGQHYEGSSHRQS

分子量

Approximately 17.0 kDa

纯度

Greater than 95% as determined by reducing SDS-PAGE

内毒素含量

<1 EU/μg, determined by LAL method.

文件资料

Cornulin Protein, Human (His) 相关分类

Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

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The reconstitution calculator equation

Volume (to add to vial) = Mass (in vial) ÷ Desired Reconstitution Concentration

Volume (to add to vial) = Mass (in vial) ÷ Desired Reconstitution Concentration
= ÷

The dilution calculator equation

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

This equation is commonly abbreviated as: C1V1 = C2V2

浓度 (start) × 体积 (start) = 浓度 (final) × 体积 (final)
× = ×
C1   V1   C2   V2

The specific activity calculator equation

Specific Activity (Unit/mg) = 106 ÷ Biological Activity (ED50)

Specific Activity (Unit/mg) = 106 ÷ Biological Activity (ED50)
Unit/mg = 106 ÷ ng/mL

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产品名称:
Cornulin Protein, Human (His)
目录号:
HY-P70116
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