2. Gene
  3. CRNN - cornulin Gene

CRNN - cornulin Gene

  • 基因
  • 蛋白
  • 疾病
  • 相关产品
  • 直系同源

中文名称：角蛋白

种属: Homo sapiens

同用名: DRC1; PDRC1; SEP53; C1orf10

基因 ID: 49860 | 基因类型: protein coding

关于 CRNN

Cytogenetic location: 1q21.3 Genomic coordinates (GRCh38): 1:152,409,243-152,414,263 (from NCBI)

This gene has 1 transcript (splice variant), 327 orthologues and 21 paralogues. Restricted expression toward esophagus (RPKM 2138.4).

功能概要

该基因编码蛋白质“融合基因”家族的成员，其中包含 N 末端 EF 手结构域和多个串联肽重复序列。编码的蛋白质在其 N 末端包含两个 EF 手 Ca2+ 结合域，在其 C 末端包含两个富含谷氨酰胺和苏氨酸的 60 个氨基酸重复序列。该基因也称为鳞状上皮热休克蛋白 53，可能在粘膜/上皮免疫反应和表皮分化中发挥作用。[RefSeq 提供，2009 年 1 月]

This gene encodes a member of the "fused gene" family of proteins, which contain N-terminus EF-hand domains and multiple tandem peptide repeats. The encoded protein contains two EF-hand Ca2+ binding domains in its N-terminus and two glutamine- and threonine-rich 60 amino acid repeats in its C-terminus. This gene, also known as squamous epithelial heat shock protein 53, may play a role in the mucosal/epithelial immune response and epidermal differentiation. [provided by RefSeq, Jan 2009]

CRNN 基因产物(1)

mRNA Protein Name
NM_016190.3 NP_057274.1 cornulin
基因本体论
  • 分子功能
  • 生物过程
  • 细胞组分
分子功能 GO 注释 逻辑证据 参考文献 来源
enables protein binding IPI
IPI: 通过物理相互作用推断
32296183 GOA
生物过程 GO 注释 逻辑证据 参考文献 来源
involved in cell-cell adhesion IDA
IDA: 通过直接分析推断
2631556 GOA
involved in cellular response to cytokine stimulus IDA
IDA: 通过直接分析推断
30009832 GOA
involved in positive regulation of NF-kappaB transcription factor activity IMP
IMP: 通过突变表型推断
30009832 GOA
involved in positive regulation of cell cycle G1/S phase transition IMP
IMP: 通过突变表型推断
30009832 GOA
involved in positive regulation of keratinocyte proliferation IMP
IMP: 通过突变表型推断
30009832 GOA
involved in regulation of gene expression IMP
IMP: 通过突变表型推断
30009832 GOA
involved in regulation of phosphatidylinositol 3-kinase/protein kinase B signal transduction IMP
IMP: 通过突变表型推断
30009832 GOA
involved in response to heat IDA
IDA: 通过直接分析推断
11606197 GOA
细胞组分 GO 注释 逻辑证据 参考文献 来源
located in cytoplasm IDA
IDA: 通过直接分析推断
15854041 GOA
located in membrane IDA
IDA: 通过直接分析推断
2980212 GOA
EXP：通过实验结果推断 IDA：通过直接分析推断 IPI：通过物理相互作用推断 IMP：通过突变表型推断 IGI：通过遗传相互作用推断 IEP：通过表达模式推断

CRNN 蛋白结构

S_100

S_100: S-100/ICaBP type calcium binding domain (4 - 45)

  • 0
  • 100
  • 200
  • 300
  • 400
  • 495 a.a.
蛋白主名 其他名称

cornulin

53 kDa putative calcium-binding protein

重组 CRNN 蛋白

目录号 产品名 蛋白编号 纯度
HY-P70116 Cornulin Protein, Human (His) Q9UBG3 (M1-S140) ≥95%

关联疾病

疾病名称 别名
Esophageal Cancer

Esophageal Carcinoma

Carcinoma Of Esophagus

Esophageal Squamous Cell Carcinoma, Somatic

Esophageal Carcinoma, Somatic

Esophagus Cancer

Gastric Cardia Adenocarcinoma

Esophageal Neoplasms

Esophageal Cancer, Somatic

Cancer Of Esophagus

Cancer Of Oesophagus

Carcinoma Of Oesophagus

Ca Lower Third Oesophagus

Ca Middle Third Oesophagus

Malignant Neoplasm Of Distal Third Of Esophagus

Malignant Neoplasm Of Lower Third Of Oesophagus

Malignant Neoplasm Of Middle Third Of Oesophagus

Malignant Neoplasm Of Proximal Third Of Esophagus

Malignant Neoplasm Of Upper Third Esophagus

Malignant Tumor Of Abdominal Esophagus

Malignant Tumor Of Distal Third Of Esophagus

Malignant Tumor Of Proximal Third Of Esophagus

Malignant Tumor Of The Middle Third Of The Esophagus

ESCR

Aerodigestive Tract Cancer

Escc

Esophageal Squamous Cell Carcinoma

Cancer, Esophageal

Malignant Neoplasm Of Esophagus

Squamous Cell Carcinoma Of Esophagus

Malignant Neoplasm Of Middle Third Of Esophagus
Squamous Cell Carcinoma

Epidermoid Carcinoma

Squamous Cell Cancer

Carcinoma, Squamous Cell

Squamous Cell Skin Cancer

Malignant Squamous Cell Tumor

Squamous Carcinoma

Squamous Cell Epithelioma

Carcinoma Squamous Cell

Neoplasms, Squamous Cell

Squamous Cell Carcinoma - Category

Malignant Squamous Cell Neoplasm

Squamous Cell Carcinoma Of Skin
Oral Squamous Cell Carcinoma

Mouth Squamous Cell Carcinoma

Squamous Cell Carcinoma Of Mouth
Psoriasis
疾病名称 别名
Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

相关产品

Pre-clinical Phase
生物活性分子 (1)
Cat. No. 产品名 作用方式
纯度 是否罕见病
HY-RS03192 CRNN Human Pre-designed siRNA Set A Pre-designed Sets / 否

直系同源

种属 基因名 来源 基因 ID
Macaca mulatta CRNN VGNC VGNC:71397
Mus musculus CRNN MGD MGI:2685861
Canis familiaris CRNN VGNC VGNC:39626
Rattus norvegicus CRNN RGD RGD:1311778
Bos taurus CRNN VGNC VGNC:27722
Others CRNN NCBI
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