CRABP2 蛋白, Human (His)

CRABP2 (cellular retinoic acid binding protein 2) plays a crucial role in cellular processes by transporting retinoic acid into the nucleus and mediating its contact with nuclear retinoic acid receptors. CRABP2 interacts with RXR (retinoic acid X receptor) and RARA (retinoic acid receptor Alpha) to regulate the retinoic acid signaling pathway. CRABP2 Protein, Human (His) is the recombinant human-derived CRABP2 protein, expressed by E. coli , with N-His labeled tag. The total length of CRABP2 Protein, Human (His) is 137 a.a., with molecular weight of ~16 kDa.

CRABP2（细胞视黄酸结合蛋白 2）通过促进视黄酸向细胞核的运输，在细胞过程中发挥关键作用，在细胞核中它调节视黄酸与核视黄酸受体的接触。通过与 RXR（视黄酸 X 受体）和 RARA（视黄酸受体 Alpha）相互作用，CRABP2 有助于调节视黄酸信号通路。此外，CRABP2 与 importin α 结合，表明它参与了复杂的核运输机制，进一步凸显了它在介导视黄酸相关细胞反应中的重要性。

Human

E. coli

N-6*His

P29373 (P2-E138)

1382  [NCBI]

PNFSGNWKIIRSENFEELLKVLGVNVMLRKIAVAAASKPAVEIKQEGDTFYIKTSTTVRTTEINFKVGEEFEEQTVDGRPCKSLVKWESENKMVCEQKLLKGEGPKTSWTRELTNDGELILTMTADDVVCTRVYVRE

Approximately 16 kDa

• 
  Greater than 95% as determined by reducing SDS-PAGE.

无菌粉末

Lyophilized from a 0.2 μm filtered solution of 50 mM Tris-HCL, 300 mM NaCl, pH 8.0.

<1 EU/μg, determined by LAL method.

It is not recommended to reconstitute to a concentration less than 100 μg/mL in ddH₂O. For long term storage it is recommended to add a carrier protein (0.1% BSA, 5% HSA, 10% FBS or 5% Trehalose).

Stored at -20°C for 2 years. After reconstitution, it is stable at 4°C for 1 week or -20°C for longer (with carrier protein). It is recommended to freeze aliquots at -20°C or -80°C for extended storage.

Room temperature in continental US; may vary elsewhere.