CRACC/SLAMF7 蛋白, Mouse (HEK293, His)

The CRACC/SLAMF7 protein is an autoligand receptor in the SLAM family that critically regulates immune cell activation and differentiation through homotypic or heterotypic interactions. It coordinates distinct immune responses, dependent on the presence or absence of the cytoplasmic linkers SH2D1A/SAP and/or SH2D1B/EAT-2. CRACC/SLAMF7 Protein, Mouse (HEK293, His) is the recombinant mouse-derived CRACC/SLAMF7 protein, expressed by HEK293 , with C-6*His labeled tag.

CRACC/SLAMF7 蛋白作为信号淋巴细胞激活分子 (SLAM) 家族中的自配体受体发挥作用。通过同型或异型细胞间相互作用，SLAM 受体调节多种免疫细胞的激活和分化，在先天性和适应性免疫反应的调节和协调中发挥着至关重要的作用。CRACC/SLAMF7 的活性受到小细胞质接头蛋白、SH2D1A/SAP 和/或 SH2D1B/EAT-2 的存在或不存在的复杂控制。该蛋白通过不依赖 SH2D1A 的细胞外信号调节 ERK 介导途径介导自然杀伤 (NK) 细胞激活，并以依赖于接头 SH2D1B 的机制正向调节 NK 细胞功能。此外，NK 细胞之间的同型相互作用可能有助于激活，但在缺乏 SH2D1B 的情况下，CRACC/SLAMF7 会抑制 NK 细胞功能。它还对 T 细胞发挥抑制作用，并可能在淋巴细胞粘附中发挥作用。在 LPS 激活的单核细胞中，CRACC/SLAMF7 负向调节促炎细胞因子的产生。该蛋白进一步与各种信号分子相互作用，包括 SH2D1B、PTPN6/SHP-1、PTPN11/SHP-2、INPP5D/SHIP1、CSK 和 FYN，突出显示其参与多种细胞过程和分子相互作用。

Mouse

HEK293

C-6*His

Q8BHK6 (S23-G224)

75345  [NCBI]

SGTLKKVAGALDGSVTFTLNITEIKVDYVVWTFNTFFLAMVKKDGVTSQSSNKERIVFPDGLYSMKLSQLKKNDSGAYRAEIYSTSSQASLIQEYVLHVYKHLSRPKVTIDRQSNKNGTCVINLTCSTDQDGENVTYSWKAVGQGDNQFHDGATLSIAWRSGEKDQALTCMARNPVSNSFSTPVFPQKLCEDAATDLTSLRG

30-38 kDa

Greater than 95% as determined by reducing SDS-PAGE.

无菌粉末.

Lyophilized from a 0.2 μm filtered solution of PBS, pH 7.4.

<1 EU/μg, determined by LAL method.

It is not recommended to reconstitute to a concentration less than 100 μg/mL in ddH₂O. For long term storage it is recommended to add a carrier protein (0.1% BSA, 5% HSA, 10% FBS or 5% Trehalose).

Stored at -20°C for 2 years. After reconstitution, it is stable at 4°C for 1 week or -20°C for longer (with carrier protein). It is recommended to freeze aliquots at -20°C or -80°C for extended storage.

Room temperature in continental US; may vary elsewhere.