2. 重组蛋白
  3. Immune Checkpoint Proteins CD Antigens
  4. Inhibitory Checkpoint Molecules T Cell CD Proteins Macrophage CD Proteins Dendritic Cell CD Proteins
  5. CTLA-4 CTLA-4
  6. CTLA-4 蛋白, Cynomolgus (HEK293, His)

CTLA-4 蛋白, Cynomolgus (HEK293, His)

目录号: HY-P7838
产品使用指南

CTLA-4 蛋白是一种关键的抑制性受体，是免疫调节中 T 细胞反应的主要负调节剂。其独特的特性在于对 B7 配体 (CD80/CD86) 的亲和力明显高于刺激性辅助受体 CD28。CTLA-4 在配体结合方面胜过 CD28，对 T 细胞活化发挥抑制作用，减轻复杂的免疫调节环境中的过度免疫反应。CTLA-4 蛋白, Cynomolgus (HEK293, His) 是重组的 CTLA-4 蛋白，由 HEK293 表达，带有 N-6*His 标签。CTLA-4 蛋白, Cynomolgus (HEK293, His) 全长 124 个氨基酸，分子量为 17-25 kDa。

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描述

CTLA-4 Protein, a pivotal inhibitory receptor, is a primary negative modulator of T-cell responses in immune regulation. Its distinctive property lies in significantly higher affinity for B7 ligands (CD80/CD86) than the stimulatory coreceptor CD28. Outcompeting CD28 for ligand engagement, CTLA-4 exerts a suppressive influence on T-cell activation, mitigating excessive immune responses in the intricate landscape of immune regulation. CTLA-4 Protein, Cynomolgus (HEK293, His) is the recombinant cynomolgus-derived CTLA-4 protein, expressed by HEK293 , with N-6*His labeled tag. The total length of CTLA-4 Protein, Cynomolgus (HEK293, His) is 124 a.a., with molecular weight of 17-25 kDa.
研究背景

CTLA-4 是一种关键的抑制性受体，在复杂的免疫调节领域中作为 T 细胞反应的主要负调节剂发挥着至关重要的作用。这种调节功能取决于 CTLA-4 的独特特性，与同源刺激辅助受体 CD28 相比，CTLA-4 对其天然 B7 家族配体 CD80 和 CD86 表现出显着更高的亲和力。这种结合亲和力的显着差异强调了 CTLA-4 在配体接合方面胜过 CD28 的能力，从而对 T 细胞激活产生抑制影响并减轻过度的免疫反应。
种属

Cynomolgus
表达系统

HEK293
标签

N-6*His
蛋白编号

G7PL88 (A37-S160)
基因 ID
蛋白结构
N-term
6*His
CTLA-4 (A37-S160)
Accession # G7PL88
C-term
同用名
rCynCytotoxic T-lymphocyte protein 4/CTLA-4, His; Cytotoxic T-lymphocyte protein 4; Cytotoxic T-lymphocyte-associated antigen 4; CTLA-4; CD152; CTLA4
氨基酸序列

AMHVAQPAVVLANSRGIASFVCEYASPGKATEVRVTVLRQADSQVTEVCAATYMMGNELTFLDDSICTGTSSGNQVNLTIQGLRAMDTGLYICKVELMYPPPYYMGIGNGTQIYVIDPEPCPDS

分子量

17-25 kDa
纯度

Greater than 95% as determined by reducing SDS-PAGE
内毒素含量

<1 EU/μg, determined by LAL method.
文件资料
产品使用指南 (1213 KB)
Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

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The reconstitution calculator equation

Volume (to add to vial) = Mass (in vial) ÷ Desired Reconstitution Concentration

Volume (to add to vial) = Mass (in vial) ÷ Desired Reconstitution Concentration
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The dilution calculator equation

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

This equation is commonly abbreviated as: C1V1 = C2V2

浓度 (start) × 体积 (start) = 浓度 (final) × 体积 (final)
× = ×
C1   V1   C2   V2

The specific activity calculator equation

Specific Activity (Unit/mg) = 106 ÷ Biological Activity (ED50)

Specific Activity (Unit/mg) = 106 ÷ Biological Activity (ED50)
Unit/mg = 106 ÷ ng/mL

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