CTLA-4 蛋白, Rhesus Macaque (HEK293, His)

CTLA-4 protein acts as a primary inhibitory receptor, playing a major role in regulating T-cell responses. Its strong affinity for CD80 and CD86 receptors allows CTLA-4 to effectively suppress T-cell activation and maintain immune balance. This interplay is crucial for fine-tuning T-cell-mediated immunity. CTLA-4 Protein, Rhesus Macaque (HEK293, His) is the recombinant Rhesus Macaque-derived CTLA-4 protein, expressed by HEK293 , with C-His labeled tag.

CTLA-4 蛋白作为主要抑制性受体发挥作用，作为 T 细胞反应的主要负调节因子发挥着至关重要的作用。CTLA-4 的显着特征在于其对其天然 B7 家族配体 CD80 和 CD86 的亲和力比其相应的刺激性辅助受体 CD28 的亲和力强得多。这种增强的亲和力使 CTLA-4 能够有效平衡和抑制 T 细胞激活，从而有助于免疫反应的复杂调节。CTLA-4 及其配体之间的动态相互作用强调了其在微调免疫系统以及维持 T 细胞介导的免疫激活和抑制之间的微妙平衡方面的重要性。

Measured by its binding ability in a functional ELISA. Immobilized recombinant cynomolgus monkey CTLA-4 at 0.5 μg/mL (100 μL/well) can bind biotinylated recombinant human B7-1. The ED₅₀ for this effect is 287.2 ng/mL.

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  Measured by its binding ability in a functional ELISA. Immobilized recombinant cynomolgus monkey CTLA-4 at 0.5 μg/mL (100 μL/well) can bind biotinylated recombinant human B7-1 .The ED₅₀ for this effect is 287.2 ng/mL.

Rhesus Macaque

HEK293

C-His

Q9BDC4 (A37-D161)

705673  [NCBI]

AMHVAQPAVVLANSRGIASFVCEYASPGKATEVRVTVLRQADSQVTEVCAATYMMGNELTFLDDSICTGTSSGNQVNLTIQGLRAMDTGLYICKVELMYPPPYYMGIGNGTQIYVIDPEPCPDSD

Approximately 25-30 kDa

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  Greater than 95% as determined by reducing SDS-PAGE.

无菌粉末

Lyophilized from a 0.2 μm filtered solution of PBS, pH 7.4.

<1 EU/μg, determined by LAL method.

It is not recommended to reconstitute to a concentration less than 100 μg/mL in ddH₂O. For long term storage it is recommended to add a carrier protein (0.1% BSA, 5% HSA, 10% FBS or 5% Trehalose).

Stored at -20°C for 2 years. After reconstitution, it is stable at 4°C for 1 week or -20°C for longer (with carrier protein). It is recommended to freeze aliquots at -20°C or -80°C for extended storage.

Room temperature in continental US; may vary elsewhere.