DEFA3/Defensin alpha 3 蛋白, Human (HEK293, Fc)

The DEFA3/defensin alpha 3 protein is a potent effector in innate immunity against a variety of infectious agents, including bacteria, fungi, and viruses. It neutralizes bacterial toxins, such as Bacillus anthracis lethal factor and Staphylococcus aureus leukocidin, and plays a key role in blocking herpes simplex virus infection by preventing viral attachment. DEFA3/Defensin alpha 3 Protein, Human (HEK293, Fc) is the recombinant human-derived DEFA3/Defensin alpha 3 protein, expressed by HEK293 , with N-hFc labeled tag. The total length of DEFA3/Defensin alpha 3 Protein, Human (HEK293, Fc) is 56 a.a., with molecular weight of ~36 KDa.

DEFA3/防御素 α 3 蛋白在先天免疫系统中充当有效的效应分子，利用抗生素样特性来对抗广泛的传染源，包括细菌、真菌和病毒。值得注意的是，它具有中和细菌毒素的能力，例如炭疽杆菌致死因子、艰难梭菌细胞毒素 B 和金黄色葡萄球菌杀白细胞素。此外，DEFA3 通过与包膜糖蛋白 B 相互作用，防止其附着于硫酸乙酰肝素（病毒附着的关键受体），从而在阻断单纯疱疹病毒感染中发挥关键作用。这种多方面的免疫活性强调了该蛋白质在宿主防御中的重要性。DEFA3 作为二聚体发挥作用，展示其在执行多种抗菌功能时的结构组织。

Human

HEK293

N-hFc

P59666 (D39-C94)

1668  [NCBI]

DIPEVVVSLAWDESLAPKHPGSRKNMDCYCRIPACIAGERRYGTCIYQGRLWAFCC

Approximately 36 kDa.

• 
  Greater than 95% as determined by reducing SDS-PAGE.

无菌粉末

Lyophilized from a 0.2 μm filtered solution of PBS, pH 7.4.

<1 EU/μg, determined by LAL method.

It is not recommended to reconstitute to a concentration less than 100 μg/mL in ddH₂O. For long term storage it is recommended to add a carrier protein (0.1% BSA, 5% HSA, 10% FBS or 5% Trehalose).

Stored at -20°C for 2 years. After reconstitution, it is stable at 4°C for 1 week or -20°C for longer (with carrier protein). It is recommended to freeze aliquots at -20°C or -80°C for extended storage.

Room temperature in continental US; may vary elsewhere.