Delta-like 蛋白 3/DLL3 蛋白, Human (Biotinylated, HEK293, His)

Delta-like protein 3/DLL3 stands out as a key regulator of neurogenesis and cell differentiation. As an inhibitor of primary neurogenesis, DLL3 plays a crucial role in guiding neurons along specific differentiation pathways. Delta-like protein 3/DLL3 Protein, Human (Biotinylated, HEK293, His) is the recombinant human-derived Delta-like protein 3/DLL3 protein, expressed by HEK293 , with N-His labeled tag.

Delta 样蛋白 3/DLL3 成为神经发生和细胞分化复杂过程中的关键调节因子。作为初级神经发生的抑制剂，DLL3被认为在引导神经元沿着特定分化途径发挥关键作用。它的参与超出了神经发生的范围，有助于轴旁中胚层分割过程中体节边界的形成。值得注意的是，DLL3 表现出结合和激活 Notch-1 或其他 Notch 受体的能力，强调了它在协调控制发育途径和细胞命运决定的细胞过程中的重要性。

1.Immobilized Anti-DLL3 Antibody, hFc Tag at 1 μg/mL (100 μl/Well) on the plate. Dose response curve for Biotinylated Human DLL3, His Tag with the EC₅₀ of 18.7 ng/mL determined by ELISA.
2.Immobilized Anti-DLL3 Antibody, hFc Tag at 2 μg/mL (100 μl/Well) on the plate. Dose response curve for Biotinylated Human DLL3, His Tag with the EC₅₀ of ≤20 ng/mL determined by ELISA.

Human

HEK293

N-His

Q9NYJ7-1 (A27-R490)

10683  [NCBI]

AGVFELQIHSFGPGPGPGAPRSPCSARLPCRLFFRVCLKPGLSEEAAESPCALGAALSARGPVYTEQPGAPAPDLPLPDGLLQVPFRDAWPGTFSFIIETWREELGDQIGGPAWSLLARVAGRRRLAAGGPWARDIQRAGAWELRFSYRARCEPPAVGTACTRLCRPRSAPSRCGPGLRPCAPLEDECEAPLVCRAGCSPEHGFCEQPGECRCLEGWTGPLCTVPVSTSSCLSPRGPSSATTGCLVPGPGPCDGNPCANGGSCSETPRSFECTCPRGFYGLRCEVSGVTCADGPCFNGGLCVGGADPDSAYICHCPPGFQGSNCEKRVDRCSLQPCRNGGLCLDLGHALRCRCRAGFAGPRCEHDLDDCAGRACANGGTCVEGGGAHRCSCALGFGGRDCRERADPCAARPCAHGGRCYAHFSGLVCACAPGYMGARCEFPVHPDGASALPAAPPGLRPGDPQR

52-62 kDa

Greater than 95% as determined by Tris-Bis PAGE.

无菌粉末

Lyophilized from a 0.22 μm filtered solution of PBS, 200 mM L-Arginine, pH 7.4. Normally 8% trehalose is added as protectant before lyophilization.

<1 EU/μg, determined by LAL method.

It is not recommended to reconstitute to a concentration less than 100 μg/mL in ddH₂O. For long term storage it is recommended to add a carrier protein (0.1% BSA, 5% HSA, 10% FBS or 5% Trehalose).

Stored at -20°C for 2 years. After reconstitution, it is stable at 4°C for 1 week or -20°C for longer (with carrier protein). It is recommended to freeze aliquots at -20°C or -80°C for extended storage.

Room temperature in continental US; may vary elsewhere.