Dihydroorotate Dehydrogenase 蛋白, Human (His)

Dihydroorotate dehydrogenase is a key enzyme that utilizes quinones as electron acceptors to catalyze the key conversion of dihydroorotate to orotic acid. This enzyme activity is essential for the de novo biosynthesis of UMP (uridine monophosphate), an essential component of nucleotide metabolism. Dihydroorotate Dehydrogenase Protein, Human (His) is the recombinant human-derived Dihydroorotate Dehydrogenase protein, expressed by E. coli , with N-His labeled tag. The total length of Dihydroorotate Dehydrogenase Protein, Human (His) is 365 a.a., with molecular weight of ~41 kDa.

二氢乳清酸脱氢酶 (DHODH) 是一种关键酶，在 UMP（尿苷单磷酸）的从头生物合成中发挥着至关重要的作用。其催化功能涉及利用醌作为电子受体将二氢乳清酸盐转化为乳清酸盐。这种酶活性对于 UMP（RNA 和 DNA 的关键成分）的生物合成至关重要。作为嘧啶生物合成的关键参与者，DHODH 有助于生成 DNA 复制和 RNA 合成等细胞过程所需的核苷酸。DHODH 在从头途径中的参与强调了其在维持嘧啶核苷酸细胞池中的重要性，使其成为各种生物过程的必需酶（改编自所提供的通道）。

Human

E. coli

N-10*His

Q02127 (T31-R395)

1723  [NCBI]

49 kDa

Greater than 90% as determined by reducing SDS-PAGE

无菌粉末.

Lyophilized from a 0.22 μm filtered solution of PBS, 6% Trehalose, pH 7.4.

<1 EU/μg, determined by LAL method.

It is not recommended to reconstitute to a concentration less than 100 μg/mL in ddH₂O.

Stored at -20°C for 2 years. After reconstitution, it is stable at 4°C for 1 week or -20°C for longer (with carrier protein). It is recommended to freeze aliquots at -20°C or -80°C for extended storage.

Room temperature in continental US; may vary elsewhere.